The goal of this research is to elucidate the mechanism of virus recognition in molecularly imprinted polymers (MIPs) using already utilized techniques. Our approach employs a more flexible non-covalent imprinting method which starts from a readily available polymer and utilizes an aqueous environment for both MIP synthesis and testing. Virus MIPs against tobacco mosaic virus (TMV) were synthes...

Molecularly imprinted polymers are versatile materials with wide application scope for the detection, capture and separation of specific compounds present in complex feed stocks. A major challenge associated with their preparation has been the need to sacrifice one mole equivalent of the template molecule to generate the complementary polymer cavities that selectively bind the target molecule. ...

Herein we report a sensor array based on quartz crystal microbalance (QCM) to simultaneously detect two biomarkers, namely low-density lipoprotein (LDL), and high-density lipoprotein (HDL). Selective recognition takes place through molecularly imprinted polymers (MIP) with both MIPs and corresponding non-imprinted polymer (NIP) as reference electrode. Sensor array performs highly appreciably in...

A series of fluorescent molecularly imprinted polymers has been prepared with a view to generating material capable of mimicking the binding characteristics of the metabolically important cytochrome isoform CYP2D6. Such polymers would have the possibility to form the sensing element in a high-throughput assay for the prediction of CYP2D6 affinity. The imprinted polymers possessed binding-depend...

Recent advances in monolithic systems, especially the development of functionalized monoliths, make it more tentative for separation science, such as enantiomer separation. Proteins, as one category of well-acknowledged chiral selectors, have won a reputation of separating a wide range of enantiomeric mixtures due to varieties of functional groups at their surface. However, the combination of p...

Although the roots of molecularly imprinted polymers lie in the beginning of 1930s in the past century, they have had an exponential growth only 40-50 years later by the works of Wulff and especially by Mosbach. More recently, it was also proved that molecular imprinted membranes (i.e., polymer thin films) that show recognition properties at molecular level of the template molecule are used in ...

− The molecular imprinting technique is a reliable technique for the preparation of materials of predetermined selectivity. It is highly significant in research of the structure of enzyme, mechanism of receptor-antibody and analytical chemistry. In analytical separation science, molecularly imprinted polymers have been applied in several analytical techniques, such as liquid chromatography, cap...

An important challenge for scientific research is the production of artificial systems able to mimic the recognition mechanisms occurring at the molecular level in living systems. A valid contribution in this direction resulted from the development of molecular imprinting. In this work, a novel molecularly imprinted polymer composite membrane (MIM) was synthesized and employed for the selective...