Bacterial and retroviral superantigens (SAGs) stimulate a high proportion of T cells expressing specific variable regions of the T cell receptor (TCR) beta chain. Although most alleles and isotypes bind SAGs, polymorphisms of major histocompatibility complex (MHC) class II molecules affect their presentation to T cells. This observation has raised the possibility that a TCR-MHC class II interac...

A canonical flow geometry was utilized for a fundamental study of the coupling between bulk flow and a Newtonian gas-liquid interface in the presence of an insoluble surfactant. We develop a Navier-Stokes numerical model of the flow in the deep-channel surface viscometer geometry, which consists of stationary inner and outer cylinders, a floor rotating at a constant angular velocity, and an int...

BACKGROUND Preclinical studies suggest that exogenous surfactant may be of value in the treatment of the acute respiratory distress syndrome (ARDS), and two phase 2 clinical trials have shown a trend toward benefit. We conducted two phase 3 studies of a protein-containing surfactant in adults with ARDS. METHODS In two multicenter, randomized, double-blind trials involving 448 patients with AR...

PURPOSE To compare the efficacy of the new drug calfactant with the commonly used drugs surfactant-TA and poractant alfa. MATERIALS AND METHODS A total of 332 preterm infants at 24-31 weeks' gestation with respiratory distress syndrome (RDS) were enrolled and allocated to three groups according to the surfactant instilled; Group 1 (n=146, surfactant-TA), Group 2 (n=96, calfactant), and Group ...

The shell liner type, rotation speed, and ball filling percent are the key factors influencing the charge behavior inside the SAG mills, and consequently, their performance. In this work, the milling operation of industrial SAG mills is investigated using the Discrete Element Method (DEM). First, an industrial SAG mill with dimensions of 9.50 m × 4.42 m that has a Smooth-type liner is sim...

We report on characterization of a 170,000 Da glycoprotein found exclusively in the PNS. We refer to this protein as the Schwann cell membrane glycoprotein (SAG). SAG contains the HNK-1 carbohydrate, which is considered by some to be a marker of adhesion molecules. Its N-terminal sequence is not similar to previously known polypeptide sequences. SAG is found exclusively in the PNS, is present i...

This study presents optimal placement of voltage sag monitors based on new Sag Occurrence Index (SOI) which ensures observability even in case of monitor failure or line outages. Multiple solutions for optimal placement of voltage sag monitors for voltage sag detection have been obtained by genetic algorithm approach such that observability of the whole system is guaranteed. A new Sag Occurrenc...

Voltage sags in the electric power system are mostly due to faults in the power system. Voltage sag is characterized by its magnitude (the retained voltage), phase-angle jump, unbalance in the sag in the three phases, and duration. Type of transformers in the electrical system is the important parameter influencing the characteristic of sag at the node where sensitive loads are connected. For s...

Horizontal gene transfer from retroviruses to mammals is well documented and extensive, but is rare between unrelated viruses with distinct genome types. Three herpesviruses encode a gene with similarity to a retroviral superantigen gene (sag) of the unrelated mouse mammary tumour virus (MMTV). We uncover ancient retroviral sags in over 20 mammals to reconstruct their shared history with herpes...