The present study is to establish bi-layer tablets of Glimepiride and Captopril, of which Glimepiride as immediate release and Captopril as sustained release layers. Immediate release layer was prepared by direct compression method by using cross povidone as disintegrant and sustained release layer was prepared by direct compression method by using HPMC K4 as polymer. Both powder blends of imme...

The drug delivery system in breast cancer therapy with the thermosensitive hydrogel method developed significantly due to influence of availability various polymers which have characteristics that are affected by changes temperature. Drug release from gel preparations has advantages over traditional intravenous release. Despite fact injectable capability gradual and sustained release, is unpred...

Monolithic matrix tablets of ambroxol hydrochloride were formulated as sustained release tablets employing hydroxypropyl methylcellulose polymer, and the sustained release behaviour of the fabricated tablets was investigated. Sustained release matrix tablets containing 75 mg ambroxol hydrochloride were developed using different drug polymer ratios of hydroxypropyl methylcellulose. Tablets were ...

The present study aimed to formulate and evaluate sustained release matrix tablets of levofloxacin to achieve sustained drug release with reduced side effects and improved patient compliance. Different batches of sustained release matrix tablets of levofloxacin were prepared by direct compression method using HPMC, sodium CMC and sodium alginate as polymers, Avicel PH 102 (MCC) as filler and st...

In current study,a hydrogel based on biocompatible polymerwas prepared. The functionalization of polyvinyl alcohol (PVA)with epichlorohydrin(ECH) to produce epichlorohydrin-g-polyvinyl alcohol (PVA/ECH) as a suitable macroinitiator for atom transfer radical polymerization (ATRP) reaction was investigated.ThenN-vinyl pyrrolidone (NVP) waspolymerized on the surface of macroinitiatorin presence of...

Formulations for sustained medication release are very useful in the treatment of chronic disorders. The oral route has selected matrix tablets as most likely type prolonged drug release. In order to generate therapeutic activity a protracted duration, maintain stable plasma concentration and sustain rate throughout time. preparations with short half-life high dosage frequency, extended-release...