Aim: To ascertain the maximum tolerated dose (MTD) and to investigate the acute oral toxic effects of imidacloprid towards Swiss albino male mice. Materials and Methods: The MTD of imidacloprid was determined in pilot dose range finding study following the standard method. Animals were observed for toxic signs and symptoms after oral administration of MTD of imidacloprid in single dose. th The ...

Background: Recently, we reported immunological and hematological perturbations in Swiss albino mice exposed to clomazone (CMZ) (Nassef, The Egyptian Journal of Experimental Biology (Zoology) 13(1):91–101, 2017). Aim: To continue searching immunological perturbations of CMZ, the main goal of the current study was to investigate the probable immunobiochemical perturbations caused by CMZ and to e...

Haematological and serum biochemical studies on Swiss albino rats were carried out for a period of 15 days to investigate the effects of untreated (Infl uent) and treated (Effl uent) textile dye wastewaters collected from an Effl uent Treatment Plant in Sanganer, Jaipur, India. In comparison to control animals (potable water), values of RBC, WBC, Hb, PCV and MCHC decreased signifi cantly in was...

Acute toxicity study of potassium permanganate was carried out in Swiss albino mice. Potassium permanganate was administered at dose rate of 0.0, 500, 1000, 1500, 2000, 2500, 3000 and 3500mg/kg body weight to groups 1, 2, 3, 4, 5, 6, 7 and 8, ten per group for LD50 determination. The dead animals were posted for gross lesions. A predetermined dose of 160mg/kg of the chemical was administered to...

Worldwide application of pesticides is increasing continually to the extent that they have become an integral part of the ecosystem. Approximately 5.6 billion pounds of active pesticide ingredients are used annually throughout the world (USEPA, 2001). Post market surveillance has revealed that as many as 25 million agricultural workers worldwide experience unintentional pesticide poisoning each...

PURPOSE Individuals with oculocutaneous albinism are predisposed to visual system abnormalities affecting the retina and retinofugal projections, which may lead to reduced visual acuity and Infantile Nystagmus Syndrome (INS). Due to absence of an established mammalian animal model, mechanisms underlying INS remain elusive. In this study, we screened wild-type mice of varying pigmentation for oc...

The sorting-out behavior (self-segregation of two cell types from mixtures of the two) of five different established cell lines was studied. Eight of the ten possible binary combinations of these lines, cultured as cellular aggregates, were examined. Mouse BALB/c 3T3 cells sorted out internally to the corresponding malignant SV40 virus-transformed 3T3 cells. The transformed 3T3 line (SVT-2) did...

Gymnema is popularly known as gurmar or Madhunashini (destroyer of sugar), as chewing the leaves causes a loss of sweet taste. Gymnema sylvestre leaves extract against 7, 12 dimethylbenz (a) anthracene (DMBA) induced papillomagenesis in Swiss albino mice was studied. The methanolic extract of Gymnema sylvestre was analyzed for chemopreventive activity. Chemopreventive activity was evaluated by ...

Swiss mice are among the most commonly used outbred strains in biomedical research. Because prior knowledge of the baseline phenotypes of mouse strains will allow informed selection of strains for particular experiments, we sought to characterize the behavior of two previously untested outbred Swiss strains--NIH Swiss and Black Swiss--in the two most widely used paradigms for evaluating the cog...

Context. The plant Citrus maxima Merr. (Rutaceae), commonly known as shaddock or pomelo is indigenous to tropical parts of Asia. The objective of present study is to evaluate the methanol extract of Citrus maxima leaves for its antitumor activity against Ehrlich's Ascites Carcinoma cell in Swiss albino mice. Experimental design. The antitumor activity of methanol extract of Citrus maxima leaves...