نتایج جستجو برای: synaptic terminal

تعداد نتایج: 207353  

Journal: :Journal of anatomy 2008
Becki Baxter Thomas H Gillingwater Simon H Parson

Motor nerve terminals are known to be vulnerable to a wide range of pathological stimuli. To further characterize this vulnerability, we have developed a novel model system to examine the response of mouse motor nerve terminals in ex vivo nerve/muscle preparations to 2 h hypoxia followed by 2 h reperfusion. This insult induced a rapid loss of neurofilament and synaptic vesicle protein immunorea...

2014
Anna R. Karataeva Remco V. Klaassen Jasper Ströder Marta Ruiperez-Alonso Johannes J. J. Hjorth Pim van Nierop Sabine Spijker Huibert D. Mansvelder August B. Smit

Shisa9 (initially named CKAMP44) has been identified as auxiliary subunit of the AMPA-type glutamate receptors and was shown to modulate its physiological properties. Shisa9 is a type-I transmembrane protein and contains a C-terminal PDZ domain that potentially interacts with cytosolic proteins. In this study, we performed a yeast two-hybrid screening that yielded eight PDZ domain-containing in...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Megan C Wright Srilatha Potluri Xueyong Wang Eva Dentcheva Dinesh Gautam Alan Tessler Jürgen Wess Mark M Rich Young-Jin Son

Muscarinic acetylcholine receptors (mAChRs) modulate synaptic function, but whether they influence synaptic structure remains unknown. At neuromuscular junctions (NMJs), mAChRs have been implicated in compensatory sprouting of axon terminals in paralyzed or denervated muscles. Here we used pharmacological and genetic inhibition and localization studies of mAChR subtypes at mouse NMJs to demonst...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Ying Lai Ucheor B Choi Yunxiang Zhang Minglei Zhao Richard A Pfuetzner Austin L Wang Jiajie Diao Axel T Brunger

Complexin activates Ca(2+)-triggered neurotransmitter release and regulates spontaneous release in the presynaptic terminal by cooperating with the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and the Ca(2+)-sensor synaptotagmin. The N-terminal domain of complexin is important for activation, but its molecular mechanism is still poorly understood. Her...

Journal: :The Journal of Cell Biology 1962
Russell J. Barrnett

A study of the cytochemical localization of acetylcholiriesterase activity, combining histochemistry with electron microscopy, showed that the final product of the reaction, which was deposited at or near enzyme sites, occurred at four places in the myoneural junction. These included: plasma membrane of the muscle covering the junctional folds, the primary and secondary synaptic clefts, parts o...

Journal: :The Journal of biological chemistry 2000
S E Craven D S Bredt

Synaptic function requires proper localization of proteins at synaptic sites. Targeting of the postsynaptic density protein 95 (PSD-95) relies on multiple signals within the protein, including twelve C-terminal amino acids. We now show that this C-terminal targeting domain of PSD-95 mediates postsynaptic localization through a short tyrosine-based motif followed by a pair of hydrophobic amino a...

Journal: :The Journal of biological chemistry 2014
Krishan K Pandey Sibes Bera Sergey Korolev Mary Campbell Zhiqi Yin Hideki Aihara Duane P Grandgenett

We determined conditions to produce milligram quantities of the soluble Rous sarcoma virus (RSV) synaptic complex that is kinetically trapped by HIV strand transfer inhibitors (STIs). Concerted integration catalyzed by RSV integrase (IN) is effectively inhibited by HIV STIs. Optimized assembly of the RSV synaptic complex required IN, a gain-of-function 3'-OH-recessed U3 oligonucleotide, and an ...

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