The syndrome of inappropriate antidiuretic hormone secretion (SIADH) remains a challenging disorder to diagnose and treat. Three cases are presented to illustrate these challenges. The first two cases had drug-induced SIADH secondary to a selective serotonin reuptake inhibitor (for depression) or carbamazepine (for trigeminal neuralgia). The third case had SIADH possibly secondary to bronchiect...

BACKGROUND The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is usually seen in pulmonary malignancies, central nervous system disorders, and secondary to medications. SIADH has very rarely been encountered in primary hepatocellular carcinoma. Two cases were reported in Japan and 1 case in Spain after extensive investigation of the medical records. CASE REPORT We report a c...

症例は73歳女性．自動車乗車中に単独事故で受傷し救急搬送された．胸部単純CTで両側多発骨折，軽度左血気胸，外傷性肝損傷を認め入院となった．入院2日目に呼吸状態が悪化，左胸腔ドレナージを行い呼吸状態は改善したが，入院3日目に痙攣及び遷延する意識障害を認めた．血液検査で著明な血清ナトリウム値低下を認め，中枢神経系疾患や副腎機能異常を認めなかったことから抗利尿ホルモン分泌異常症候群（syndrome of inappropriate secretion antidiuretic hormone：SIADH）と診断した．補液による電解質補正にて血清ナトリウム値は速やかに正常化し，意識も改善した．

Hyponatraemia is the commonest electrolyte abnormality found in hospital inpatients, and is associated with a greatly increased morbidity and mortality. The syndrome of inappropriate antidiuretic hormone (SIADH) is the most frequent cause of hyponatraemia in hospital inpatients. SIADH is the clinical and biochemical manifestation of a wide range of disease processes, and every case warrants inv...

An 11-year-old boy developed severe syndrome of inappropriate antidiuretic hormone secretion (SIADH) after diagnosis of an intracranial B-cell lymphoma. His sodium levels dropped to 118-120 mmol/L despite 70% fluid restriction. For chemotherapy, he required hyperhydration, which posed a challenge because of severe hyponatraemia. Tolvaptan is an oral, highly selective arginine vasopressin V2-rec...

lung cancer is associated with anti-Hu paraneoplastic LE. Since the report of Fukushima et al. [1] , we have shown the serum of their patient to be strongly positive for VGKC-Ab (2,354 p M ). The antibody titre decreased during treatment to 901 p M . This test is a radioimmunoassay utilising the binding of 125 I-radiolabelled -dendrotoxin to specific potassium channels. The results are expresse...

OBJECTIVE There is a major problem about the incidence, diagnosis, and differentiation of cerebral salt wasting syndrome (CSWS) and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in patients with acute central nervous system (CNS) disorders. According to rare reports of these cases, this study was performed in children with acute CNS disorders for diagnosis of CSWS versus S...

It is well documented that central nervous system (CNS) infections may lead to syndrome of inappropriate anti-diuretic hormone secretion (SIADH), but diagnosing these can prove difficult in patients with atypical presentations. We present a case of SIADH and muscle weakness in a patient without typical signs of CNS infection who was tested and diagnosed with neuroborreliosis based largely on he...

Hyponatremia is a common finding after subarachnoid hemorrhaging (SAH) and can be caused by either cerebral salt-wasting syndrome (CSWS) or syndrome of inappropriate antidiuretic hormone (SIADH). Distinguishing between these two entities can be difficult because they have similar manifestations, including hyponatremia, serum hypo-osmolality, and high urine osmolality. We herein report the case ...