Temporary remission of scleroderma during the successful treatment of an associated malignant lymphoma by chemotherapy is reported in a patient with systemic sclerosis and mixed connective tissue disease. There is a well established relation between malignant disease and polymyositis/dermatomyositis but no overall association with systemic sclerosis or mixed connective tissue disease. Reports o...

Platelet serotonin concentrations were measured in 43 patients with systemic sclerosis, in 11 patients with primary Raynaud's phenomenon, and in 38 normal controls. Patients with the CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) had significantly lower platelet serotonin concentrations than normal controls. Patients with diffuse systemi...

Diabetic sclerodactyly is a frequently recognized skin finding that may occur in patients with diabetes mellitus but coexistence of diabetes and systemic sclerosis is rare. We describe a case of coexistence of type 1 diabetes mellitus and systemic sclerosis in 42-year-old man with the history of Raynaud's phenomenon, progressive diffuse hardening of the skin and sclerodactyly, slowly worsening ...

2015 Systemic sclerosis remains one of the most clinically challenging diseases for rheumatologists and patients continue to suffer from a considerable degree of morbidity and mortality. Even though the pathogenesis of the disease remains complex and poorly understood, new research over the past several years have brought us closer to an understanding of the underlying disease mechanisms and co...

Systemic sclerosis affects multiple internal organs and systems and is characterized by high clinical variability. Early diagnosis of the disease itself and of organ involvement plays a key role in the management of systemic sclerosis. The prognosis for each patient is equally important. In recent years there has been significant progress in our understanding of the pathogenesis and clinical co...