The aerial part of Salvia wiedemannii Boiss. (Lamiaceae) has been used for treatment of peptic ulcers and relieving pain in Turkish folk medicine. To evaluate the analgesic effect of S. wiedemannii, tail flick and acetic acid-induced writhing tests were used in mice. The chloroform extract (500 mg/kg, i.p.) obtained from S. wiedemannii showed significant analgesic activity on tail flick assay, ...

Ligustrum robustum is an indigenous medicinal shrub that belongs to the family, Oleaceae. It is a major component of Chinese tea, Ku-Ding-Cha, which is used to prevent common cold, rhinitis, itching eyes, and headache. The present study was undertaken to evaluate the anti-inflammatory and analgesic activities of the aqueous extract of Ligustrum robustum (ALR) in experimental animal models. ALR ...

In the traditional medicine, Taxus baccata Linn. has been used as analgesic, anticonvulsant, and antiinflammatory remedy. In the present study, bark of plant was extracted with 95% ethanol and ether at room temperature and evaluate for their analgesic activity in mice using the tail-flick and acetic acid-induced writhing method. Ether extract exhibits potent analgesic activity in tail-flick tes...

Objective: The present study was aimed to find out the central and peripheral analgesic activity of aqueous leaf extract of Solanum melongena Linn (AESML) in experimental animals. Methods: Preliminary phytochemical analysis of AESML was performed by chemical tests. The central analgesic activity was measured by tail flick method in Wistar rats and peripheral analgesic activity was measured by a...

Beta-endorphin (fS-EP) is a 31 amino acid polypeptide secreted by the pituitary, brain, and various other tissues. it has potent opiate-like activity, can produce analgesia, and may play a physiological role in adapting the immune system to stress by affecting Iymphocyte and complement binding activity. To investigate the effect of fS-EPon pain threshold, we analyzed cerebrospinal fluid (CSF) a...

introduction: oxytocin is a active neuropeptide of central nervous system. in this study the effects of naloxone (opioid receptor antagonist) and yohimbine (α-2 adrenergic receptor antagonist) on analgesic effect of oxytocin applied into the locus coeruleus (lc) nucleus were investigated. methods: adult male wistar rats were used. animals divided into different groups receiving saline, oxytocin...

The ethanolic extract of the leaves of Tamarindus indicus was investigated for its anti inflammatory and analgesic actions. The anti inflammatory activity was studied using carrageenin induced hind paw edema in rats and analgesic activity using chemical writhing test and tail clip method in mice and tail flick method yin rats. Test drug exhibited significant dose dependent anti inflammatory and...

Some 1,5-diaryl-3-ethoxycarbonyl-2-methylpyrrole derivatives were obtained by reacting 1-aryl-3-ethoxycarbonylpent-1,4-diones and a suitable aniline derivative or sulfanilamide under Paal-Knorr pyrrole synthesis conditions. The cytotoxicity of the compounds was tested and all compounds, except for compound 2 h, showed a time-dependent increase in cytotoxic activity. Analgesic activities of the ...

The roots of Flemingia strobilifera were extracted in absolute methanol to determine their analgesic activity. The analgesic activity was assessed on intact mice by tail flick latency in tail immersion method. Acetylsalicylic acid in the dose of 300 mg/kg is used as standard drug. Plant extracts were given in the doses of 300, 500 and 1000 mg/kg. Control group received 0.9% NaCl (saline) soluti...