Chemoradiation is the standard therapy for the majority of inoperable, locally advanced cancers. Although there is a need to improve chemoradiation efficacy, normal-tissue toxicity limits our ability to give additional chemotherapy or higher doses of radiation. Thus, there is excitement about the addition of molecularly targeted agents, which tend to be less toxic than chemotherapy, to chemorad...

Introduction: Radiation-induced cardiovascular damage is a potential side effect of radiation therapy in patients with left-sided breast cancer. This prospective study compares the severity and reversibility of perfusion and functional abnormalities before, and six months after, 3D-Conformal radiation therapy treatment in left-side breast cancer patients with conventional and h...

BACKGROUND Radiation maculopathy is a phenomenon that occurs after radiation exposure. The rapid onset of unilateral macular atrophy without peripheral retinopathy after radiation has rarely been described. METHODS A case report and literature review. RESULTS We report a case of stage 4 non-small cell lung cancer under targeted therapy using Gefitinib who presented with severely impaired vi...

PurposeWe examined how radiation dose per fraction (DPF) and total dose, as represented by biological effective (BED), can independently differentially affect the immunomodulatory capacity of therapy (RT).Methods MaterialsAT3-OVA mammary MC38 colorectal tumors in C57BL/6 mice were irradiated with rationally selected dose-fractionation schedules, alone or immune-modulating -depleting agents. Tum...

Malignant pleural mesothelioma is a rare primary tumor rising from the pleura and is associated with exposure to asbestos fibers. Mesothelioma is a locally aggressive disease that usually presents at an advanced stage and has a median overall survival of 1 year. Treatment options rarely result in cure of disease and range from trimodality treatment, including chemotherapy, radiation, and surger...

Radiation recall dermatitis has been documented to occur in previously irradiated skin (within the radiation port) the administration of some chemotherapeutic agents. Clinically, it can occur weeks or months after radiation therapy, and resembles the appearance of acute radiation skin reaction. The patterns of the reaction correspond with radiation fields and skin doses. We report a case of rec...

As well as being a significant source of environmental radiation exposure, α-particles are increasingly considered for use in targeted radiation therapy. A better understanding of α-particle induced damage at the DNA scale can be achieved by following their tracks in real-time in targeted living cells. Focused α-particle microbeams can facilitate this but, due to their low energy (up to a few M...