نتایج جستجو برای: tau convolution

تعداد نتایج: 37435  

Journal: :Vision Research 1997
N. P. Smith T. D. Lamb

A minimally invasive technique is described for recording the a-wave of the human ERG and extracting the parameters of transduction in the rod and cone photoreceptors. A corneal DTL fibre electrode is used, but the pupil is not dilated and the cornea is not anaesthetized. Although the amplitude of the signal collected by the DTL electrode varies from session to session, this is not a problem, a...

Journal: :Brain : a journal of neurology 2003
Prudence M Stanford Claire E Shepherd Glenda M Halliday William S Brooks Peter W Schofield Henry Brodaty Ralph N Martins John B J Kwok Peter R Schofield

The majority of cases with frontotemporal dementia (FTD) have no tau deposition in the brain, yet mutations in the tau gene lead to a similar clinical phenotype with insoluble tau depositing in neuropathological lesions. We report two tau gene mutations at positions +19 and +29, in the intronic sequences immediately following the stem loop structure in exon 10, which segregate with FTD. Exon-tr...

Journal: :IJWMIP 2011
R. S. Pathak

Translation and convolution associated with discrete wavelet transform are investigated using properties of Calderón-Zygmund operator and Riesz fractional integral operator. Dual convolution is also studied. The wavelet convolution is applied to approximate functions belonging to certain p L-spaces.

Journal: :CoRR 2017
Andrew P. Aitken Christian Ledig Lucas Theis Jose Caballero Zehan Wang Wenzhe Shi

Convolutional neural networks (CNNs) are a popular and highly performant choice for pixel-wise dense prediction or generation. One of the commonly required components in such CNNs is a way to increase the resolution of the network’s input. The lower resolution inputs can be, for example, low-dimensional noise vectors in image generation [7] or low resolution (LR) feature maps for network vis...

2018
Norimichi Shirafuji Tadanori Hamano Shu-Hui Yen Nicholas M Kanaan Hirotaka Yoshida Kouji Hayashi Masamichi Ikawa Osamu Yamamura Masaru Kuriyama Yasunari Nakamoto

Increased plasma homocysteinemia is considered a risk factor of dementia, including Alzheimer's disease (AD) and vascular dementia. However, the reason elevated plasma homocysteinemia increases the risk of dementia remains unknown. A pathological hallmark of AD is neurofibrillary tangles (NFTs) that consist of pathologically phosphorylated tau proteins. The effect of homocysteine (Hcy) on tau a...

2012
Vanessa Plouffe Nguyen-Vi Mohamed Jessica Rivest-McGraw Johanne Bertrand Michel Lauzon Nicole Leclerc

It is well established that tau pathology propagates in a predictable manner in Alzheimer's disease (AD). Moreover, tau accumulates in the cerebrospinal fluid (CSF) of AD's patients. The mechanisms underlying the propagation of tau pathology and its accumulation in the CSF remain to be elucidated. Recent studies have reported that human tau was secreted by neurons and non-neuronal cells when it...

Journal: :Journal of Alzheimer's disease : JAD 2011
Donna M Barten Gregory W Cadelina Nina Hoque Lynn B DeCarr Valerie L Guss Ling Yang Sethu Sankaranarayanan Paul D Wes Marianne E Flynn Jere E Meredith Michael K Ahlijanian Charles F Albright

Levels of tau in cerebrospinal fluid (CSF) are elevated in Alzheimer's disease (AD) patients. It is believed this elevation is related to the tau pathology and neurodegeneration observed in AD, but not all tauopathies have increased CSF tau. There has been little pre-clinical work to investigate mechanisms of increased CSF tau due to the difficulty in collecting CSF samples from mice, the most ...

2010
Stephanie J. Adams Michael A. DeTure Melinda McBride Dennis W. Dickson Leonard Petrucelli

Tauopathies are defined by assembly of the microtubule associated protein tau into filamentous tangles and classified by the predominant tau isoform within these aggregates. The major isoforms are determined by alternative mRNA splicing of exon 10 generating tau with three (3R) or four (4R) approximately 32 amino acid imperfect repeats in the microtubule binding domain. In normal adult brains t...

2014
Sergio Camero María J. Benítez Raquel Cuadros Félix Hernández Jesús Ávila Juan S. Jiménez

Tau hyperphosphorylation can be considered as one of the hallmarks of Alzheimer's disease and other tauophaties. Besides its well-known role as a microtubule associated protein, Tau displays a key function as a protector of genomic integrity in stress situations. Phosphorylation has been proven to regulate multiple processes including nuclear translocation of Tau. In this contribution, we are a...

2013
Amy M Pooler Emma C Phillips Dawn H W Lau Wendy Noble Diane P Hanger

Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown. We show that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from healthy, mature cortical neurons. Notably, phosphorylation of extracellular tau appears reduced in comparison with intracellular tau. We also find that...

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