BACKGROUND Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. METHODS AND RESULTS To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic circulation, we measured, in 5 healthy volunteers, the distribution of radioact...

OBJECTIVE A subset of parathyroid adenomas contains a relative overabundance of oxyphil cells that are capable of greater technetium Tc 99m sestamibi tracer uptake and retention than other cell types. We examined whether the presence of oxyphil cells augments the sensitivity of technetium Tc 99m sestamibi preoperative localization and whether the histologic findings of a lesion could be predict...

twenty-one patients with medullary thyroid carcinoma were studied prospectively with tc-99m (v) dmsa after surgery. pentavalent dmsa scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. finally, seven patients with surgical or other imaging documentation were selected for this paper. most of these patients were asymptomatic. six patients had hypercalcitonemia and se...

Introduction: Endometriosis is a gynecological disease and disorder that occurs when endometrial cells are shed through the fallopian tubes and are implanted on the surfaces of pelvis and abdomen. They form lesions that respond to hormones of the menstural cycle and will stimulate inflammation. It is controversial whether [99mTc]Tc-RBC scan would be sufficient for lo...

BACKGROUND AND OBJECTIVES Technetium-99m 2-methoxy-isobutyl-isonitrile ((99m)Tc-sestamibi) has recently been proposed as a potential tracer in patients with multiple myeloma (MM), as its increased uptake in the bone marrow has been reported as indicator of myeloma activity. We evaluated the role of (99m)Tc-sestamibi scintigraphy in the detection of myeloma bone disease in MM and related gammopa...

A 45-yearold man with dyspnea was referred for lung perfusion scan. Extrapulmonary uptake of Tc-99m macroaggregated albumin (MAA) was noted in a small area of the liver and in the thoracic vertebrae (fig. 1); the findings were not seen in a repeated lung scan after administration of the tracer through a peripheral vein in the foot (fig. 2). Subsequent computed tomography of the thorax revealed ...

99mTc-sestamibi, a substrate of the multidrug transporter P-glycoprotein (Pgp), has been used as a functional imaging agent for the multidrug resistance-1 (MDR1) phenotype. In vitro, retention of (99m)Tc-sestamibi by cells that overexpress Pgp can be enhanced by the addition of Pgp inhibitors. XR9576 (Tariquidar) is a potent and selective noncompetitive inhibitor of Pgp that is active at 25-80 ...

Four patients with sonographic suggestion of hepatic hemangioma are studied with Tc99m-labeled RBC scan. The scan findings are compaired with other imaging modalities. Lesions as small as 36 mm could be detected by this method. Tc99m labeled RBC scan is a valuable tool to differentiate hepatic hemangioma from other space occupying lesion of the liver.