Objectives: Multidrug resistance (MDR), which may be due to the over expression of P-glycoprotein (Pgp) and/or MRP, is a major problem in neoadjuvant chemotherapy of osteosarcoma. The aim of this study was to investigate the role of Tc-99m MIBI scan for predicting the response to pre-operative chemotherapy. Materials and Methods: Twenty-five patients (12 males and 13 females, aged between 8 and...

cystatin c is a 13 kd basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. the cystatin c gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin c by most cells. this protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. because of these ch...

Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...

Ectopic thyroid tissue in the lower neck with a coexisting normally located multinodular goiter is a rare entity. We present a 27-year old asymptomatic woman with a recent history of a painless mass in the left side of her lower neck. Thyroid function tests were normal. An ultrasound of her neck showed a multinodular goiter and a 3.4 cm solid mass in the left lower cervical area. These findings...

BACKGROUND In postmenopausal women, the presence of risk factors for coronary artery disease (CAD) increases. However, the difference in prevalence of ischemia between pre- and postmenopausal women with multiple risk factors for CAD has not been well established. OBJECTIVES To compare the prevalence of ischemia on Tc99m-sestamibi myocardial perfusion scintigraphy (MPS) in pre- and postmenopau...

Quantitative SPECT as well as simultaneous acquisition of multiple isotopes with SPECT in the clinical field, although clinically interesting, are still limited by reconstruction artifacts and computing power. As a considerable step in this direction, we have implemented an efficient reconstructor with variance reduced Monte-Carlo-simulation in the forward and/or backward projection of an OS-EM...

OBJECTIVE It has been reported that both obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) might be related to impairments in frontal-striatal brain circuits. Besides, these two disorders are frequently comorbid. However, there are no published studies directly comparing the neurobiological findings in these two disorders. The objective of the study was to ...