نتایج جستجو برای: tcells
تعداد نتایج: 170 فیلتر نتایج به سال:
T-lymphocytes are a numerically small subset of T-lymphocytes which differ from conventional Tlymphocytes primarily in respect to the ligands recognized by the T-cell antigen receptor. In this regard, human T-cells differ significantly from their murine counterpart, because only human but not mouse T-cells recognize small phosphorylated metabolites that are produced by many bacteria and parasit...
The genes of the human Major histocompatibility complex (MHC) on the short area of chromosome 6, play a crucial role in the recognition of “self’ from “non-self”. In man this complex is referred to as the Human Leucocyte Antigen (HLA) system. These HLA antigens are grouped as Class I and Class II depending on their distribution on nucleated cells. HLA antigens (three of Class I, HLAs A, B and C...
Immune therapy has shifted the paradigm of modern cancer treatment: Instead of targeting the tumor itself, it focuses on enhancing tumor recognition and destruction. Harnessing the immune system by using monoclonal antibodies, adoptive T cell transfer or checkpoint inhibitor (CPI) therapy increased progression free survival with less side effects compared to conventional therapy [1]. Checkpoint...
Hobey Tam, Nathaniel Parchment, Narendra Vyavahare Clemson University, Clemson, SC Introduction: Glutaraldehyde (GLUT) treated bioprosthetic heart valves (BHVs) are the only option for valve replacement with a 10-15 years implant life. A major failure mode of GLUT BHVs is calcification. The exact mechanisms of calcification are poorly understood. There are two hypotheses put forth as to how cal...
The pig demonstrates prominent delayed-type hypersensitivity (DTH) reactions following contact sensitization with dinitrofluorobenzene (DNFB) [l]. The process of sensitization is thought to occur by epidermal Langerhan'dveiled cells which migrate from DNFB-painted skin to the paracortical region of the draining lymph nodes (LN) [2]. Here. presentation of DNFB-haptenated neoantigens to T cells m...
Non-animal test methods for skin sensitization have to consider the complex interactions of chemicals with the different parts of the skin immune system (Cumberbatch et al., 1992). A few chemicals act as prohaptens and can be converted to a hapten by oxidation, skin metabolism, or ultraviolet radiation (Karschuk et al., 2010). the hapten (parent or converted chemical) may penetrate the skin and...
Despite advances in research and treatment modalities, colorectal cancer still accounts for around half a million deaths yearly worldwide. Traditional and even newer pharmaceutical therapeutic regimens are limited in terms of tolerance, efficacy and cross-resistance. Additional non-cross resistant therapies with non-overlapping toxicities are needed to improve the outcome for patients with colo...
Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid der...
Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes. Vitamin D acts via its receptor (VDR). Four single nucleotide polymorphisms (SNPs) of the VDR gene have been commonly studied, and evidence of association with type 1 diabetes has been reported previously. We sequenced the VDR gene region and developed its SNP map. ...
The immune system must be educated to discriminate between the body’s own tissues (‘self’) and foreign pathogenic microorganisms (non-self). This ability is acquired by T lymphocytes in the thymus (central tolerance) and it is further refined by peripheral tolerance. Errors in discrimination potentially result in autoimmune diseases, such as type 1 diabetes, in which the insulinproducing beta c...
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