In the current technology dominated world, interoperability of systems managed by different organisations is an essential property enabling the provision of services at a global scale. In the Text and Data Mining field (TDM), interoperability of systems offering access to text corpora offers the opportunity of increasing the uptake and impact of TDM applications. The global corpus of all resear...

Therapeutic drug monitoring (TDM) is defined as the clinical laboratory measurement of the levels of drugs in plasma, serum or blood of patients that, with appropriate medical interpretation, will directly influence drug prescribing procedures [1]. TDM is also referred to as the individualization of drug dosage by maintaining plasma or blood drug concentrations within a targeted therapeutic ran...

Trehalose 6,6'-dimycolate (TDM) is a cell wall glycolipid and an important virulence factor of mycobacteria. In order to study the role of TDM in the innate immune response to Mycobacterium tuberculosis, microarray analysis was used to examine gene regulation in murine bone marrow-derived macrophages in response to 90-μm-diameter polystyrene microspheres coated with TDM. A large number of genes...

あらまし 直交周波数分割多重(OFDM: Orthogonal frequency division multiplexing)と時分割多重(TDM: Time division multiplexing)とを組み合わせた OFDM/TDMは,周波数領域等化(FDE: Frequency-domain equalization)を用いること で OFDMとシングルキャリア(SC: Single carrier)伝送を橋渡しできる伝送方式である.FDEのためには高精度なチャ ネル推定が必要である.周期的に送信された既知パイロットを用いるチャネル推定が知られている.チャネル推定 に誤差があると OFDM/TDMでは符号間干渉(ISI: Inter-symbol interference)が発生してしまう.本論文では推定し たチャネルインパルス応答にガウス分布する誤差が存在するとするガウス...

Biologic drugs have revolutionised many medical conditions. Like all medicines there is a role for therapeutic drug monitoring (TDM) with some agents in The utility of TDM biologic will be explored, covering methods detection as well the evidence that effective or otherwise.

We evaluate improvements in information capacity gained by use of time-division multiplexing (TDM) in three-dimensional integral imaging (II) systems. This analysis supports the motivation for two TDM methods in II [Opt. Lett. 27, 324 (2002); 1144 (2002)] that we previously developed.

Abstract Background Therapeutic drug monitoring (TDM) of infliximab (IFX) in patients with Crohn’s disease (CD) and ulcerative colitis (UC) is increasingly used clinical routine, although proactive TDM still controversial. Nevertheless, activity clearance are higher at the induction phase leading to an increased risk inadequate exposure treatment failure. The aim study was evaluate efficacy imp...

TDM and exposure–response relationships TDM is the measurement and interpretation of drug concentrations in biological fluids so as to determine the correct drug dosage for an individual patient.1 The technique requires that dose be correlated with exposure and that exposure be correlated with pharmacodynamic (PD) response. Exposure metrics include the pharmacokinetic (PK) parameters: area unde...

Cell cycle control is modified at meiosis compared to mitosis, because two divisions follow a single DNA replication event. Cyclin-dependent kinases (CDKs) promote progression through both meiosis and mitosis, and a central regulator of their activity is the APC/C (Anaphase Promoting Complex/Cyclosome) that is especially required for exit from mitosis. We have shown previously that OSD1 is invo...

Monoclonal antibodies specific for the cyclobutane pyrimidine dimer (CPD) are widely used for detection and quantification of DNA photolesions. However, the mechanisms of antigen binding by anti-CPD antibodies are little understood. Here we report NMR analyses of antigen recognition by TDM-2, which is a mouse monoclonal antibody specific for the cis - syn -cyclobutane thymine dimer (T[ c, s ]T)...