Marija RADENKOVIĆ Clinic for Eye Diseases Clinical Center of Niš Bulevar dr Zorana Djindjića 48 18000 Niš Serbia [email protected] SUMMARY Introduction Ocular surface disease (OSD) is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbances, tear film instability with potential damage to the ocular surface, accompanied by increased tear ...

BACKGROUND Chronic dry eye disease often requires long-term therapy. Tear film alterations in the setting of dry eye may include reduced tear volume as well as an increase in inflammatory cytokines and osmolarity. Topical cyclosporine ophthalmic emulsion 0.05% (Restasis(®); Allergan Inc, Irvine, CA) is indicated to increase tear production in patients with dry eye and reduced tear production pr...

PURPOSE To investigate whether exposure of human corneal epithelial cells to hyperosmotic stress activates the c-Jun NH(2)-terminal kinase (JNK) stress-activated protein kinase (SAPK) pathway, and stimulates production of the matrix metalloproteinases (MMPs): gelatinase (MMP-9), collagenases (MMP-1 and -13), and stromelysin (MMP-3). METHODS Primary human corneal epithelial cells cultured in n...

Background: Dry Eye Disease (DED) is a prevalent condition that involves instability, increased osmolarity, and inflammation of the tear film ocular surface. Vitamin D known for its anti-inflammatory properties. Association between vitamin deficiency incidence DED has been suggested. However, no study currently exists systematically reviews potential role as treatment DED. Methods: The literatu...

PURPOSE The aim of the present study was the in vitro and in vivo evaluation of a novel aqueous formulation based on polymeric micelles for the topical delivery of cyclosporine A for dry eye treatment. METHODS In vitro experiments were carried out on primary rabbit corneal cells, which were characterized by immunocytochemistry using fluorescein-labeled lectin I/isolectin B4 for the endothelia...

PURPOSE To identify the diurnal variations of tear osmolarity (TO) and its relationship with central corneal thickness (CCT) and corneal deswelling over a 14-hour period. METHODS TO and CCT were measured using the TearLab Osmometer and Bioptigen spectral domain optical coherence tomography, respectively, on 38 healthy neophytes (mean age, 21.5 ± 2.2 years). TO and CCT were measured at bedtime...

Patients with clinically well defined keratoconjunctivitis sicca (KCS) participated in two trials of hypo-osmolar tear substitutes. The trials were double masked, single crossover studies with computer generated random order allocation and were conducted by postal questionnaire. In the first trial a hypo-osmolar formulation using polyvinylpyrrolidone and hydroxyethyl cellulose was compared with...