A new strategy to package "problematic" transgenes in adenovirus was developed that was based on modifications of the tetracycline-inducible system. This strategy used two components: the adenoviral genome containing the transgene under control of a hybrid TRE promoter/SV40 enhancer and a trans-encoded tTS suppressor Using luciferase reporters, expression of tTS in 293A cells reduced transcript...

We propose three enhancements to the treeto-string (TTS) transducer for machine translation: first-level expansion-based normalization for TTS templates, a syntactic alignment framework integrating the insertion of unaligned target words, and subtree-based ngram model addressing the tree decomposition probability. Empirical results show that these methods improve the performance of a TTS transd...

1414 school children (789 boys and 625 girls) residing in east-Tehran, were evaluated for the evidence of goiter. 88% of girls and 71.5% of boys had goiter. In 30% of girls and 17.5% of boys goiter was clearly visible (grade 2 and over). FT4I, FT3I, TSH, and thyroglobulin concentrations were not significantly different in groups with or without goiter. The concentration of iodide in urine was 2...

As the Internet grows in scale almost every year, security measures are expected to become all the more important on the Internet. A time-stamping authority (TSA) is a trusted authority which provides a proof that a datum existed before a particular time. In this research, we designed and implemented a RFC3161-compliant trusted time-stamping service (TTS) over the Internet. Software for the TTS...

In a process known as quorum sensing, bacteria communicate with one another by producing, releasing, detecting, and responding to signal molecules called autoinducers. Vibrio harveyi, a marine pathogen, uses two parallel quorum-sensing circuits, each consisting of an autoinducer-sensor pair, to control the expression of genes required for bioluminescence and a number of other target genes. Gene...

To the Editor I read with great interest the study by Blumstein et al. [1], published online ahead of print on 21 July 2015 in the Journal, about capture myopathy (CM) and its clinical implications for human Takotsubo syndrome (TTS), which reminded me of the seminal work done by Ueyama et al. [2] with their rat immobilization animal model of TTS. The capacity of the brain to injure the heart is...

We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow- derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol regulates naïve CD8+ T-cell polarization by modulating GSK-3β activity in IFN-γ-stimulated BMDCs, an...

BACKGROUND Some epidemiological evidence has shown a relation between ambient air pollution and adverse health outcomes. The aim of this study was to investigate the effect of air pollution on mortality from respiratory diseases in Tehran, Iran. METHODS In this ecological study, air pollution data was inquired from the Tehran Province Environmental Protection Agency and the Tehran Air Quality...

CONTEXT Renewal of fentanyl transdermal patch (transdermal therapeutic system [TTS]) should occur every 3 days (72 hours) according to manufacturer's guidelines. Some studies mentioned patients reporting end-of-dose failure, and thus, some authors recommend shortening the interval of application to 2 days (48 hours). However, reasons for early replacement are mostly unknown. OBJECTIVES The ob...

Speech synthesis or text-to-speech (TTS) systems are currently available for a number of the world’s major languages, but for thousands of other, unsupported, languages no such technology is available. While awaiting the development of such technology, we propose using an existing TTS system for a major language (the base language, BL) to “fake” TTS for an unsupported language (the target langu...