Temporary pacemakers are classically indicated for severe bradydysrhythmia, especially when the clinical settings require prompt intervention. Implantation of a temporary pacemaker is not a benign procedure since it may be associated with serious adverse events such as infection, cardiac perforation, and lead dislodgment. Accordingly, we recommend, when the clinical condition allows, to proceed...

Hypertension is the risk factor of serious cardiovascular diseases, such as ischemic heart disease and atherosclerosis. The aim of the present study was to analyze the development of cardiac tolerance to ischemia in neonatal spontaneously hypertensive rats (SHR) and possible protective effect of ischemic preconditioning (IP) or adaptation to intermittent high-altitude hypoxia (IHAH). For this p...

INTRODUCTION Disturbances of the cardiac conduction system are potential complications after cardiac valve surgery. OBJECTIVES This study was designed to investigate the association between perioperative factors and atrio-ventricular block, the need for temporary cardiac artificial pacing and, if necessary, permanent pacemaker implantation after cardiac valve surgery. METHODS Retrospective ...

Elevated cardiac triacylglycerol (TAG) content is traditionally equated with cardiolipotoxicity and suggested to be a culprit in cardiac dysfunction. However, previous work demonstrated that myosin heavy-chain-mediated cardiac-specific overexpression of diacylglycerol transferase 1 (MHC-DGAT1), the primary enzyme for TAG synthesis, preserved cardiac function in two lipotoxic mouse models despit...

OBJECTIVE To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats. METHOD 20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion: 10 under normothermia and 10 under mild hypothermia (32 masculine C). Brain coronal sections 2mm thick were stained with 2,3,5-triphenyltetrazolium hydrochloride, photographed and evaluated ...

The left cerebral hemisphere of Mongolian gerbils was used to elucidate the mechanisms of brain edema which develop during cerebral ischemia and after restoration of cerebral blood flow following temporary ischemia. Water content was measured by the tissue-drying method. Sodium and potssium ion concentration was measured by flame photometry. Passage of 131I-albumin (RISA) from blood to the cere...

We tested the hypothesis that cardiac ischemia uncouples the beneficial interaction among hyperkalemia, acidosis, and raised plasma catecholamines when these chemicals are changed to mimic their exercise levels. Potassium chloride, lactic acid, and norepinephrine (NE) were infused intravenously for 2 min into anesthetized, artificially ventilated, thoracotomized rabbits during either occlusion ...

BACKGROUND Our center has been performing beating heart coronary artery bypass grafting with a temporary intraluminal shunt since 1983. Based on our clinical observations of more than 846 surgical cases, we believe that a temporary intraluminal shunt (TIS) greatly reduces the risk of the patient developing regional myocardial ischemia during clamping of the coronary artery. To seek evidence in ...

Spinal cord ischemia was produced in rabbits by temporary occlusion of the abdominal aorta just distal to the renal arteries; and recovery, or failure to recover, was assessed by examining the rabbits for permanent loss of sensory and motor function in the hind limbs. A temperature reduction of 3 degrees C during the period of circulatory impairment caused a doubling of the duration of ischemia...