HYPOTHESIS Many authors suggest that subscapularis deficiency after shoulder arthroplasty has a negative effect on long-term outcomes. Thus, increasing emphasis has been placed on the technique for repair of the tendon. This study evaluated the biomechanical strength of 3 different repairs: osteotomy, tendon to bone, and a combined method. MATERIALS AND METHODS Twenty-four paired shoulders fr...

INTRODUCTION The obesity epidemic has resulted in a large increase in type 2 diabetes (T2D). While some secondary complications of T2D are well recognized and their cellular and molecular mechanisms are defined, the impact of T2D on the musculoskeletal system is less understood. Clinical evidence suggests that tendon strength and repair are compromised. Here, a mouse model of obesity and T2D re...

INTRODUCTION Although patellar tendon injuries are common but chronic patellar tendon rupture are rare injuries but severely disabling. Problems associated with this injury are scar formation, atrophy and contracture of the quadriceps, poor quality of remaining reabsorbed tendon, inadequate soft tissue, proximal patellar migration and prolonged post operative immobilization. Hence these injurie...

Background: Tendon defects remain a major concern in orthopedic surgery because of the limited availability of tendon autografts. Since the extracellular collagen-based matrix derived from porcine small intestinal submucosa (SIS) has been successfully used in repair of many tissues, such as abdominal wall, vessels and bladder, we hypothesized that SIS can be used to repair an experimentally ind...

The repair of tendon injuries still presents a major clinical challenge to orthopedic medicine. Tendons, like some other tissues, are poorly vascularized and heal slowly. In addition, healing often leads to the formation of fibrous tissue and scar tissue which lack flexibility and biomechanical properties. So the treatment of tendon injuries is challenging. We give an overview of the structure ...

objectives: the objective was to determine the results of early active controlled motion in the patients rehabilitated by our new protocol. methods: 91 fingers in 64 patients with flexor tendon repair in all zones were enrolled in a single group (quasi-experimental) clinical trial. 58 fingers in 43 patients were assessed at least three months postoperatively. outcomes were defined using the ‘wh...

PURPOSE This study compares rotator cuff repair strength after cyclic loading of bioabsorbable tacks and traditional transosseous sutures, and correlates the results with bone density, age, and gender. The hypotheses were that tack repair strength would be inferior to transosseous sutures and that repair strength would be directly related to bone quality. TYPE OF STUDY In vitro randomized bio...

Edsfeldt, S. 2017. Intrasynovial flexor tendon injuries and repair. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1307. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9838-2. Complications after surgical repair of intrasynovial flexor tendon injuries in the hand occur despite advanced suture techniques and structured postoperative rehabil...

During the past 20 years, the difficult process of reestablishing satisfactory function after primary repair of flexor tendons has evolved from scientifically unsupported trial-and-error efforts to protocols based on sound laboratory and clinical investigations. Enhanced appreciation of tendon structure, nutrition, and biomechanical properties and investigation of factors involved in tendon hea...

BACKGROUND Tendon is a mechanical tissue that transmits forces generated by muscle to bone in order to allow body motion. The molecular pathways that sense mechanical forces during tendon formation, homeostasis and repair are not known. EGR1 is a mechanosensitive transcription factor involved in tendon formation, homeostasis and repair. We hypothesized that EGR1 senses mechanical signals to pro...