In general, at most institutions pregnancy has been a contraindication for giving gadolinium-containing contrast media based the principle of not exposing the fetus to drugs and the unknown teratogen risk to the fetus. However, when reviewing the literature there is no evidence that gadolinium agents cause chromosomal damage or teratogen effect (1-4). There are no reports in the literature on n...

The distinction between histiotrophic nutrition (in which local macromolecules are chiefly responsible for the maintenance of the embryo) and hemotrophic nutrition (which results from a transfer of material between the maternal and fetal circulations) is made. Placentation in a number of commonly used laboratory animals and in man is described, and it is shown that dependence upon histiotroph a...

Aflatoxin M1 (AFM1) is a potent carcinogen, teratogen and mutagen found in the milk when lactating animals consume feed contaminated with aflatoxin B1 (AFB1). In the present study, the contamination of AFM1 was evaluated in the milk supply chain of the province of Sindh, Pakistan. For the broader profiling of targeted toxin, enzyme-linked immunosorbent assay (ELISA) was used for the determinati...

Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisens...

Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but underlying molecular and synaptic alterations remain unknown. We therefore studied plasticity-related mechanisms in the neocortex of 2-week-old rats p...

OBJECTIVE The objective of this study was to report the outcomes of intrauterine pregnancies misdiagnosed as ectopic and exposed to methotrexate, a major teratogen. STUDY DESIGN We report the outcomes of all subjects who sought consultation after exposure to high-dose methotrexate to induce abortion in presumed ectopic pregnancies, which were later identified as viable intrauterine pregnancie...

Family history captures the collective influence of shared genetic susceptibility, shared environmental factors, and common behaviors within families. Throughout the reproductive continuum, pediatricians, obstetricians, family practitioners, genetic counselors, and other clinicians can work with families to elicit relevant family history information and factor it into risk-assessment calculatio...

To describe drug prescriptions in pregnant women France and to identify teratogenic fetotoxic prescriptions. This study was carried out using data from Échantillon Généraliste des Bénéficiaires (EGB), a French national health database which includes 1/97th of the population. Our population included all women, aged 10 60, who were registered EGB had pregnancy outcome between 2015 2016. Drugs pre...