Methomyl is an oxime carbamate pesticide that is widely used in the Philippines. This insecticide is known to be an endocrine disrupting chemical and a potent genotoxic in mammalian cells. However, limited studies were conducted specifically on its direct effects on estrous cycle and its teratogenic effect. This study aimed to (a) assess the effect of methomyl on the body weight and on the estr...

BACKGROUND Estimating the true risk of fetal malformations attributable to the use of medications is difficult and perception of risk by health professionals will impact their counseling and treatment of patients who need medication during pregnancy. The objective of this study was to assess the perception of the teratogenic risk of 9 commonly and 3 rarely prescribed drugs among general practit...

BACKGROUND The rationale for use of drugs during pregnancy requires a careful assessment as in addition to the mother, the health and life of her unborn child is also at stake. Information on the use of drugs during pregnancy is not available in Pakistan. The aim of this study was to evaluate the patterns of drug prescriptions to pregnant women in tertiary care hospitals of Pakistan. METHODS ...

The fetus and placenta are an immunologically privileged unit, whose physiological changes during pregnancy intervenes in the behavior against SARS-CoV- 2, describing a theoretical potential teratogenic damage due to receptors ACE-2 expression, necessary for SARS-CoV-2 intracellular transport epiblast, vital organogenesis, as well current pharmacological therapy effects, abortions, fetal demise.

OBJECTIVES The aim of this study was to determine the teratogenic effects of carbamazepine (CBZ) in BALB/c mice. MATERIALS AND METHODS Mature female and male BALB/c mice (25-30 g) were used for all experiments. After standardization of administration and dose of CBZ, animals in the CBZ-treated groups (CBZ 450 mg/kg and 600 mg/kg) were fed on medicinal diet. The dams in the control group were ...

BACKGROUND Lead remains a considerable occupational and public health problem, which is known to cause a number of adverse effects in both men and women. Conflicting reports have appeared on lead induced nephrotoxicity in experimental studies in the past. There is hardly any work on its teratogenic effects on kidney. Present study was therefore designed to investigate the effects of lead acetat...

Epidemiologic studies of malformations can aid in the understanding of human teratogenesis. Employing a variety of approaches epidemiology can develop or test hypotheses concerning possible causes or through surveillance provide data useful for a variety of purposes. Drawing heavily upon our experiences at the Center for Disease Control, this paper reviews some concepts and uses of epidemiology...