The treatment of antihistamine and steroid resistant Chronic Idiopathic Urticaria (CIU) during pregnancy poses a challenge due to teratogenicity of immunosuppressants. Omalizumab is a recently FDA approved therapy for CIU and is classified as pregnancy category B. We present an initial series of subjects treated at a tertiary care center for antihistamine and steroid resistant CIU with omalizum...

Major birth defects affect 3 to 5% of all live births. Most are of unknown etiology, but 1 to 3% of these are thought to be due to pharmaceutical or environmental agents. A teratogen is any chemical, pharmacologic, environmental, or mechanical agent that can cause deviant or disruptive development of the conceptus. Included in this definition are functional impairment, growth restriction, and c...

Trauma is a leading cause of morbidity and mortality amongst females childbearing age, traumatic brain injury (TBI) carries significant proportion share trauma all kinds. during pregnancy has twofold impact on the patient foetus, who, most time, remains unnoticed. Understanding managing altered maternal physiology in background TBI challenge requires close monitoring to avoid any unwanted outco...