BACKGROUND Vertebral fractures increase the risk of new vertebral fractures; however, we are not aware of any study addressing the risk of new vertebral fractures adjacent to existing vertebral fractures. Therefore, we sought to determine the influence of the number and severity of prevalent (preexisting) vertebral fractures on the risk of new adjacent vertebral fractures and to determine wheth...

BACKGROUND Steroid associated osteonecrosis is difficult to treat. Teriparatide, as the only one bone anabolic drug, has achieved very promising effect in osteoporosis and other bone skeletal diseases. We carried out this animal study to evaluate the effect of subcutaneous injection of teriparatide for the steroid induced femoral head necrosis in a rat model. METHODS 24 Sprague-Dawley male ad...

As a result of aging population, the incidence of pelvic insufficiency fracture has been increasing. Pain-related immobility caused by pelvic insufficiency fractures may result in a serious dependency and high mortality with preexisting comorbidities. We present two cases of pelvic insufficiency fracture in elderly patients which had good clinical outcome by parathyroid hormone 1-34(teriparatid...

Background The bone mineral density (BMD) surrogate threshold effect (STE) is the change in BMD that can predict a fracture risk reduction with 95% certainty. STE estimates for changes total hip have been recently validated by FNIH-ASBMR SABRE Project. Objectives We evaluated proportion of patients reaching STEs anti-osteoporotic medications real-life. Methods retrieved longitudinal data on wom...

Studies examining real-world effectiveness of osteoporosis therapies are beset by limitations due to confounding by indication. By evaluating longitudinal changes in fracture incidence, we demonstrated that osteoporosis therapies are effective in reducing fracture risk in real-world practice settings. INTRODUCTION Osteoporosis therapies have been shown to reduce incidence of vertebral and non...