five-zone simulating moving bed (smb) system, designed for ternary separation, is a modified form of standard four-zone smb which is only effective in binary separation. it was reported in literature that the five-zone smb separates the extract-ii stream with a lower purity value than that of raffinate and extract-i streams. to address this issue, five zone smb was designed, using safety margin...

We previously reported that a human analogue of pulmonary surfactant protein-C (SP-C), SP-CL16 (6-28), with 23 residues was the most active analogue in a reconstituted lipid mixture and had the shortest chain among the poly leucine analogues examined. In this study, we verified the influence of albumin, a component of serum, on the surface activity of surfactant. Surface activity was measured u...

BACKGROUND Analysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been recently evolved with no limitation. A study of different novel and smart spectrophotometric techniques for resolution of severely overlapping spectra were presented in this work utilizing isosbestic points present in different absorptio...

Co-amorphous drug amino acid mixtures were previously shown to be a promising approach to create physically stable amorphous systems with the improved dissolution properties of poorly water-soluble drugs. The aim of this work was to expand the co-amorphous drug amino acid mixture approach by combining the model drug, naproxen (NAP), with an amino acid to physically stabilize the co-amorphous sy...

A binary solvent mixture close to critical demixing experiences fluctuations whose correlation length, ξ, diverges as the critical point is approached. The solvent-mediated (SM) interaction that arises between a pair of colloids immersed in such a near-critical solvent can be long-ranged and this so-called critical Casimir interaction is well-studied. How a (dense) suspension of colloids will s...

Forming complexes with cyclodextrins can enhance the dissolution rate, the stability, the solubility and the bioavailability of a drug. In this work, piroxicam/β-cyclodextrin complexes were prepared at solid state by means of supercritical carbon dioxide. The influence of temperature, residence time, water content and a ternary agent, L-lysine, were studied. The complex was characterized by Dif...

Simple, accurate and precise spectroflourometric and spectrophotometric methods have been developed and validated for the determination of sitagliptin phosphate monohydrate (STG) and metformin HCL (MET). Zero order, first derivative, ratio derivative spectrophotometric methods and flourometric methods have been developed. The zero order spectrophotometric method was used for the determination o...