The 84-kDa hormone-sensitive lipase (gene designation Lipe; EC 3.1.1.3) is a cholesterol esterase and triglyceride hydrolase that functions in the release of fatty acids from adipocytes. The role of hormone-sensitive lipase in other tissues such as the testis, where a specific 120-kDa testis-specific isoform is expressed, is unknown. To study this, we examined the fertility and testicular histo...

BACKGROUND Testicular biopsy is an acknowledged method of examination of the testes for diagnostic and therapeutic purposes. We describe the pattern of testicular histologies in our environment. MATERIALS AND METHODS We carried out a retrospective review of testicular histology results from the Pathology Department of Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, over a 5-year p...

Intratesticular injections of glycerol have been shown to result in a marked and prolonged reduction of spermatogenesis, accompanied by increased permeability of the blood-testis barrier. Because the permeability of the blood-testis barrier is regulated by Sertoli cell tight junctions, and tight junction organization is regulated by the cytoskeleton, we undertook to examine the effects of glyce...

Endoplasmic reticulum (ER) stress generally occurs in secretory cell types. It has been reported that Leydig cells, which produce testosterone in response to human chorionic gonadotropin (hCG), express key steroidogenic enzymes for the regulation of testosterone synthesis. In this study, we analyzed whether hCG induces ER stress via three unfolded protein response (UPR) pathways in mouse Leydig...

A histological study of the testes of stags shot in autumn (sexual season) and spring (quiescent period) indicated that the 3-fold increase in testicular size observed in the autumn was accompanied by increases in nearly all features studied (volumes of intertubular tissue, Leydig cells, blood vessels and peritubular cells; diameter and length of seminiferous tubules; the number of A1 spermatog...

Objectives: Quantify the distribution of collagen and analyze the seminiferous tubules diameter in the testis of patients with cryptorchidism, to verify if the previous use of human chorionic gonadotrophin (hCG) affects these structures. Material and Methods: Samples of parenchymal tissue of cryptorchid testis obtained during peroperative biopsies were collected from 26 patients. Sixteen sample...

1. Clinical History A 41 year-old male presented to his primary care provider for prostate screening. The patient had a history of hypogonadism and low testosterone, as well as a family history of prostate cancer. Physical exam demonstrated significant left scrotal swelling. Palpation of the right testicle was normal. Palpation of the left testicle was limited secondary to scrotal swelling. A s...

BACKGROUND Testicular damage due to spermatic cord torsion may lead to infertility. It is probably because of changes in oxidative stress factors such as malondialdehyde. OBJECTIVE To investigate the protective effect of melatonin (MLT), as an antioxidant, on testicular damage induced by acute unilateral spermatic cord torsion and detorsion (T/D) in rats. MATERIALS AND METHODS In this exper...

Sexual maturation of post-smolts is a concern for Atlantic salmon producers, and its occurrence dependent upon factors such as water temperature energy availability, among others. The present study was designed to investigate the effect different temperatures feeding regimes on testis development local regulation spermatogenesis in post-smolts. A 3 × 2 factorial design used, with three (8 °C, 1...