نتایج جستجو برای: tetrazine
تعداد نتایج: 409 فیلتر نتایج به سال:
The straightforward access to a new class of aza-polyaromatics is reported. Starting from readily available fluorinated s-tetrazine, cyclization process with azide leads the formation an unprecedented tetrazo[1,2-b]indazole or bis-tetrazo[1,2-b]indazole (cis and trans conformers). Based on nitrogen core, further N-directed palladium-catalyzed ortho-C−H bond functionalization allows introduction...
The pretargeting system based on the inverse electron demand Diels-Alder reaction (IEDDA) between trans-cyclooctene (TCO) and tetrazine (Tz) combines the favorable pharmacokinetic properties of radiolabeled small molecules with the affinity and specificity of antibodies. This strategy has proven to be an efficient method for the molecularly targeted delivery of pharmaceuticals, including isotop...
Alginate hydrogels are well-characterized, biologically inert materials that are used in many biomedical applications for the delivery of drugs, proteins, and cells. Unfortunately, canonical covalently crosslinked alginate hydrogels are formed using chemical strategies that can be biologically harmful due to their lack of chemoselectivity. In this work we introduce tetrazine and norbornene grou...
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