Marine pufferfish generally involve a potent neurotoxin, tetrodotoxin (TTX), which might be the leading cause for many human intoxications. It blocks nervous impulses’ conduction along nerve fibers and axons during act, LD50 mouse is 10 nanograms. Being much larger than sodium ion, TTX acts as cork of bottle, prevents from flowing until it diffuses slowly. The expanse appears to species-specifi...

イムノクロマト法を用いたテトロドトキシン（TTX）検査キットの有効性について検討した。マトリックス非存在下では，0.0125-0.2マウス単位 (MU)/mLの濃度範囲で，テストプレートに形成されるCラインとTラインの強度比（T/C）とTTX濃度の対数の間に強い負の相関が認められ，終濃度約0.06 MU/mLを検出限界として目視によりTTXの有無を判定することができた。一方，マトリックスが存在する場合，その影響を前処理で低減しても偽陽性が出やすかったが，偽陰性は全く認められなかった。

Experiments were undertaken to verify the existence of fast sodium channels in the adrenal chromaffin cell membrane and to assess their contribution to the physiological release of catecholamines. We have used veratridine to activate sodium channels. Veratridine causes secretion of catecholamines from perfused cat adrenal gland. Secretory response to veratridine is calcium dependent and abolish...

Four neurotoxins that activate the action potential Na+ ionophore of electrically excitable neuroblastoma cells interact with two distinct classes of sites, one specific for the alkaloids veratridine, batrachotoxin, and aconitine, and the second specific for scorpion toxin. Positive heterotropic cooperativity is observed between toxins bound at these two classes of sites. Tetrodotoxin is a nonc...

Homeostatic scaling allows neurons to alter synaptic transmission to compensate for changes in network activity. Here, we show that suppression of network activity with tetrodotoxin, which increases surface expression of AMPA receptors (AMPARs), dramatically reduces levels of the deSUMOylating (where SUMO is small ubiquitin-like modifier) enzyme SENP1, leading to a consequent increase in protei...