نتایج جستجو برای: tgfbr2
تعداد نتایج: 564 فیلتر نتایج به سال:
BACKGROUND Excessive accumulation of extracellular matrix (ECM) proteins is the hallmark of fibrotic diseases, including skin fibrosis. This response relies on the activation of dermal fibroblasts that evolve into a pro-fibrogenic phenotype. One of the major players in this process is the cytokine transforming growth factor-β (TGF-β). MicroRNAs (miRNAs) are small non-coding RNAs that post-trans...
The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We found the ablation of TGF-β signaling could inhibit the cancer cell proliferation,...
1 Young T, Peppard PE, Taheri S. Excess weight and sleep-disordered breathing. J Appl Physiol 2005; 99: 1592–1599. 2 Ferrannini E, Natali A, Bell P, et al. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Investig 1997; 100: 1166–1173. 3 Tasali E, Mokhlesi B, Van, et al. Obstructive sleep apnea and type 2 diabetes: interacting e...
Transforming growth factor beta (TGFb) is a potent inducer of epithelial-mesenchymal transition. Of all members the TGFb receptor family only TGFbR2 capable direct binding to ligand. In experimental conditions interactions were shown between and AR signaling pathways, often leading negative feedback loops. However, data on expression levels both receptors in clinical cancer samples are scarce. ...
Introduction ▼ Loeys–Dietz is an autosomal dominant aortic aneurysm syndrome with widespread systemic involvement. The disease is characterized by the triad of arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate and is caused by heterozygous mutations in the genes encoding transforming growth factor β receptors 1 and 2 (TGFBR1 and TGFBR2, respectively) (B.L. Loeys ...
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