Second-generation tyrosine kinase inhibitors (2G-TKIs) are effective at inducing complete cytogenetic responses (CCyRs) in approximately half of chronic myeloid leukemia patients treated while still in the chronic phase and after failing imatinib. It is less clear whether these responses are durable. In the present study, we report the clinical outcome of 119 patients who received a 2G-TKI as s...

The 1G/2G polymorphism of matrix metalloproteinase 1 (MMP-1) affects activity of the promoter in transient transfections, and has been associated with the incidence or invasiveness of five types of cancer. In light of these findings, and because stromal cells may contribute to tumor cell invasion, we used quantitative real-time reverse transcription-PCR to measure endogenous MMP-1 mRNA expressi...

matrix metalloproteinases (mmps) play an important role in gastric cancer (gc). accumulated evidence suggests that functional mmp-1 and mmp-7 gene polymorphisms are associated with several tumors. the aim of this study was to investigate two single nucleotide polymorphisms, mmp-1 -1607 1g/2g and mmp-7 -181 a/g, and their potential relationship with gc. we examined 246 gc  patients and 252 age-a...

We consider the identity component of Sato-Tate group Jacobian curves form $$C_1\colon y^2=x^{2g+2}+c, C_2\colon y^2=x^{2g+1}+cx, C_3\colon y^2=x^{2g+1} +c,$$ where $g$ is genus curve and $c\in\mathbb Q^*$ constant. approach this problem in three ways. First we use a theorem Kani-Rosen to determine splitting Jacobians for $C_1$ 4 5 prove what each case. then higher by finding maps lower computi...

Smart phones owe some of their multimode, multiband capabilities to multithrow antenna switches. As mobile handsets evolve, a single antenna switch may handle as many as 10 transmit (Tx) and/or receive (Rx) ports. The challenges facing multithrow antenna switches for these applications are not trivial but, fortunately, solutions exist for managing high throw counts while still maintaining excel...

The purpose of this paper is to examine the major factors surrouding and contributing to the creation (and success) of Europe's 2nd generation 'GSM' cellular system, and compare and contrast it to key events and recent developments in 3rd generation 'IMT-2000' systems. The objective is to ascertain whether lessons from the development of one system can be applied to the other, and what implicat...