To investigate the protein phosphatases that dephosphorylate TP, human embryonic kidney cells (HEK293 cells) stably transfected with 12CA5-tagged TP were treated with TP agonist, washed, and then allowed to recover in the presence or absence of the cell-permeable PP1 and PP2A inhibitors calyculin or okadaic acid (OKA). After recovery, cells were rechallenged with TP agonist and TP responsivenes...

The role of thromboxane (TP) in the vasoconstriction induced by tubuloglomerular feedback or 18-h ureteral obstruction was studied in wild type mice (TP +/+), and in heterozygous (TP +/-) and homozygous TP receptor knockout mice (TPR -/-). TGF function was assessed from the response of stop flow pressure (PSF) to a maximum increase in loop of Henle flow rate (0-30 nL min-1). PSF fell by 6.4 +/-...

Thymidine phosphorylase (TP) is an enzyme involved in reversible conversion of thymidine to thymine. TP is identical to an angiogenic factor, pletelet-derived endothelial cell growth factor (PD-ECGF) and the expression levels of TP in a variety of malignant tumors were higher than the adjacent non-neoplastic tissues. To investigate the molecular basis for the effect of TP on the metabolic proce...

After oral administration in rodents, triptolide (TP), a diterpenoid triepoxide compound, active as anti-inflammatory, immunosuppressive, anti-fertility, anti-cystogenesis, and anticancer agent, is rapidly absorbed into the blood circulation (from 5.0 to 19.5 minutes after dosing, depending on the rodent species) followed by a short elimination half-life (from about 20 minutes to less than 1 ho...

Department of Pharmaceutics, IPS College of Pharmacy, Gwalior,(M.P.) India Abstract In the present study, spherical microspheres of theophylline (TP) using sodium alginate as the hydrophilic carrier were prepared to prolong the release. The shape, surface and size characteristics were determined by scanning electron microscopy. The microspheres were found to be discreet and spherical in shape a...

Objective: COVID-19 infection has the potential to affect cardiovascular system as well respiratory disease. Recent studies have suggested that Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios may be associated with ventricular arrhythmias. The goal of this study is evaluation ratios, in patients Covid-19 infected or without pneumonia.
 Material Method: 118 were divided into 2 groups: pneumonia...