BACKGROUND Alveolar soft part sarcoma (ASPS) is an extremely rare metastatic soft tissue tumor with a poor prognosis for which no effective systemic therapies have yet been established. Therefore, the development of novel effective treatment approaches is required. Tyrosine kinases (TKs) are being increasingly used as therapeutic targets in a variety of cancers. The purpose of this study was to...

The use of sea buckthorn fruits in medicine, cosmetology and as a source ingredients that improve the quality food has already been studied continues to be studied. One these can serve pectin substances buckthorn, isolated from it its pure form. Considering relevance this direction, main task work was study identification wild growing Azerbaijan. Using cavitation-membrane technology, samples po...

Malignant cells build up a protective shield in form of fibrin meshwork surrounding the tumor which helps it to escape body’s immune system. In addition, and stromal provide with an abundant extracellular matrix (ECM) consisting proteoglycans, collagens, glycoproteins glucosaminoglycans additional scaffold capacity bind large quantities immunsuppressive substances. Many investigations found tha...

Natural antioxidants (NAs) are promising substances, which established as potent therapeutic agents. However, the anticancer potential of many them is not completely known. In this research, effect three natural including geraniol (Ge), citronellol (Cit), and quercetin (Qu), their combination by estimating cytotoxicity on Hela cells at doses from 15.625 to 1000 µg/mL was investigated. Moreover,...

Background and objectives: The cholinergic deficit correlates with the severity of Alzheimer’s disease. The cholinergic function can be improved by AChE inhibitors blocking this key enzyme in the breakdown of acetylcholine. Based on traditional medicine, during two last decades the use of herbal medicinal substances in dementia therapy has been studied. Nardostachys jataman...

Background and objectives: The cholinergic deficit correlates with the severity of Alzheimer’s disease. The cholinergic function can be improved by AChE inhibitors blocking this key enzyme in the breakdown of acetylcholine. Based on traditional medicine, during two last decades the use of herbal medicinal substances in dementia therapy has been studied. The fruit extract of <em...

In situ ophthalmic gel is a type of eye drug preparation that has higher bioavailability value and longer contact time with maximum therapeutic effect minimal side effects compared to conventional preparations. The in required characterization make sure the prepared preparations meet standards are safe when used. This journal review aims look at methods used characterizing physical properties f...

background:naltrexone is a competitive opioid receptor antagonist blocking the euphoric effects of exogenous opioids. when used concomitantly with opioids, naltrexone causes severe withdrawal symptoms.the main aim of the study is to determine the symptomatology and outcome of patients who consumed naltrexone in conjunction with an opioid substance. methods:this cross-sectional study was perform...

Abstract The utilization of bioactive constituent peels and seeds provide an effective, environment friendly inexpensive therapy for different forms human disease, the production, improvement documentation novel nutraceuticals. This review systematically presents findings further understanding reported benefits therapeutic applications peel seed extracts on innovative cell culture animal studie...