The discovery of C9orf72 mutations as the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has awakened a surge of interest in deciphering how mutations in this mysterious gene cause disease and what can be done to stop it. C9orf72 harbors a hexanucleotide repeat, GGGGCC, in a non-coding region of the gene and a massive expansion of this repeat ...

BACKGROUND Compliance is a key element in the success of therapy, both in practice and research. A study from 1974 demonstrated that compliance in clinical trials was only determined in 19% of studies requiring it. OBJECTIVES The objective was to determine if there has been an improvement in compliance assessment in clinical trials. METHODS All drug studies published in the British Medical ...

Pregnancy in women with pulmonary arterial hypertension (PAH) is considered to be associated with prohibitive maternal mortality. During the past decade, new advanced therapies for PAH have emerged and progress in high-risk pregnancy management has been made. We examined whether these changes have improved outcomes in parturients with PAH. A systematic review of all cases of parturients with id...

The case study provides a qualitative analysis of best practice in intellectual property strategy and commercialisation at Polartechnics Limited. A case study protocol was developed and used to conduct a face-to-face interview with the company’s Principal Scientist. Polartechnics core business is to develop and commercialise instrumentation for the screening and detection of normal, pre-cancer ...

Of Thesis Author (full names): Timothy James Bowman Title of thesis: SPIRITUALITY AT WORK: AN EXPLORATORY SOCIOLOGICAL INVESTIGATION OF THE FORD MOTOR COMPANY Degree: PhD Spirituality in the context of work has become increasingly topical but there has been little empirical or specifically sociological research conducted to date. After reviewing this research, a case study is reported of a Bene...