نتایج جستجو برای: thioredoxin
تعداد نتایج: 6000 فیلتر نتایج به سال:
Oxidative stress, which is associated with an increased concentration of reactive oxygen species (ROS), is involved in the pathogenesis of numerous diseases including cancer. In response to increased ROS levels, cellular antioxidant molecules such as thioredoxin, peroxiredoxins, glutaredoxins, DJ-1, and superoxide dismutases are upregulated to counteract the detrimental effect of ROS. However, ...
Thioredoxin is an essential protein present in all known biological systems responsible for mediating the major pathway through which electrons are transferred from NADP(H) to protein disulfide bonds: NADP(H) R-S-SR 3NADP R-SH HS-R .1,2 Thus, the discovery that thioredoxin-interacting protein (Txnip) bound to and inhibited thioredoxin–NADPH–dependent reduction of protein disulfides3 predicted t...
Cysteine dithiol/disulphide exchange forms the molecular basis for regulation of a wide variety of enzymatic activities and for transduction of cellular signals. Thus, the search for proteins with reactive, accessible cysteines is expected to contribute to the unravelling of new molecular mechanisms for enzyme regulation and signal transduction. Several methods have been designed for this purpo...
Thioredoxin, a ubiquitous 12-kDa regulatory disulfide protein, was found to reduce disulfide bonds of allergens (convert S-S to 2 SH) and thereby mitigate the allergenicity of commercial wheat preparations. Allergenic strength was determined by skin tests with a canine model for food allergy. Statistically significant mitigation was observed with 15 of 16 wheat-sensitive animals. The allergenic...
Dr. Arne Holmgren (Ph.D., 1968) is recognized here as a redox pioneer, because he has published at least one article on redox biology that has been cited over 1000 times and has published at least 10 articles, each cited over 100 times. He is widely known for his seminal discoveries and in-depth studies of thioredoxins, thioredoxin reductases, and glutaredoxins. Dr. Holmgren, active throughout ...
Petra Langlotz, Wolfgang Wagner, and Hartmut Follmann Fachbereich Chemie der Philipps-Universität, Biochemie, Hans-Meerwein-Straße. D-3550 Marburg, Bundesrepublik Deutschland Z. Naturforsch. 41c, 979—987 (1986); received August 1/September 19, 1986 Am ino Acid Composition, A lgae, Ribonucleotide Reductase, Scenedesmus obliquus, Thio redoxin A comprehensive thioredoxin profile of Scenedesmus ob...
Hydrogen sulfide (H2S) has emerged as a signalling molecule capable of regulating several important physiological functions such as blood pressure, neurotransmission and inflammation. The mechanisms behind these effects are still largely elusive and oxidative posttranslational modification of cysteine residues (protein persulfidation or S-sulfhydration) has been proposed as the main pathway for...
Chemotherapy for adult T-cell leukemia (ATL) has been reported to fail to induce complete remission because of drug resistance in most patients. We have examined the expression of an ATL-derived factor (ADF)/thioredoxin in relation to resistance to adriamycin (ADM) in various T-cell leukemia cell lines including ATL cell lines. Immunoblot analysis demonstrated that ATL cell lines expressed ADF/...
Possible target proteins of cytosolic thioredoxin in higher plants have been investigated in the cell lysate of dark-grown Arabidopsis thaliana whole tissues. We immobilized a mutant of cytosolic thioredoxin, in which an internal cysteine at the active site was substituted with serine, on CNBr activated resin, and used the resin for the thioredoxin-affinity chromatography. By using this resin, ...
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