In a previous communication (1) we reported that the sera of intact, -normal rats of the Long-Evans strain, when examined electrophoretically in saline-sodium phosphate buffer at pH 7.4, contained little or none of the protein component usually designated as a-globulin. In contrast, sera taken from rats 21 days after hypophysectomy uniformly showed the presence of this component. Earlier experi...

Peroxidase metabolism of 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) was evaluated in vitro and in vivo. In vitro metabolism of ANFT was characteristic of the hydroperoxidase activity of prostaglandin H synthase. The peroxidase inhibitors, 6-n-propyl-2-thiouracil and methimazole, significantly reduced ANFT binding to trichloroacetic acid precipitable material and glutathione conjugate formation....

The aim of the present work is to determine the influence of C5 substitution on the photophysical properties of 2-thiopyrimidines (2-TPyr). For this purpose, 2-thiouracil, 5-t-butyl-2-thiouracil and 2-thiothymine (TU, BTU and TT, respectively) have been selected as target thionucleobases for the experimental studies and, in parallel, for DFT theoretical calculations. The UV spectra displayed by...

Single-atom substitution within a natural nucleobase-such as replacing oxygen by sulfur in uracil-can result in drastic changes in the relaxation dynamics after UV excitation. While the photodynamics of natural nucleobases like uracil are dominated by pathways along singlet excited states, the photodynamics of thiobases like 2-thiouracil populate the triplet manifold with near unity quantum yie...

Mrs. G. W. was first admitted to hospital in 1932 at the age of 21 with a diagnosis of thyrotoxicosis. Both lobes of the thyroid were uniformly enlarged, and a fortnight after admission the right lobe and the isthmus were removed. During convalescence she developed nasal catarrh with fever, and Mr. Pavey-Smith reported that both tonsils were infected. At the same time the histological report on...

ORBITAL DECOMPRESSION P. R. R. CLARKE (Middlesbrough) discussed a series of 20 patients with endocrine exophthalmos treated by lateral orbital decompression. There had been 14 bilateral decompressions, and in six patients a unilateral operation only had been performed. One patient had needed reoperation. Four patients had no thyroid abnormality, and two had untreated hyperthyroidism. In 14 pati...