In the context of correlated multiple tests, we aim to nonasymptotically control the family-wise error rate (FWER) using resampling-type procedures. We observe repeated realizations of a Gaussian random vector in possibly high dimension and with an unknown covariance matrix, and consider the oneand two-sided multiple testing problem for the mean values of its coordinates. We address this proble...

In museums, it is critical to properly conserve the existing artwork. For this purpose, it is fundamental to continuously monitor its environment, either in storage or exhibition rooms. Contrarily to traditional measuring equipments and procedures used in museums, the deployment of a Wireless Sensor Network (WSN) can help to implement these measurements continuously, in a real-time basis, and i...

The approach of controlling the false discovery rate (FDR) which is less conservative than controlling the family wise error rate (FWER) has become a new and popular multiple testing procedure in microarray studies. In addition to multiple testing problems the limitation of sample size is another big challenge in this area. This thesis addresses the problem of multiple testing in the context of...

Genetic association tests involving copy-number variants (CNVs) are complicated by the fact that CNVs span multiple markers at which measurements are taken. The power of an association test at a single marker is typically low, and it is desirable to pool information across the markers spanned by the CNV. However, CNV boundaries are not known in advance, and the best way to proceed with this poo...

OBJECTIVES Discussion of different error concepts relevant to microarray experiments. Review of some commonly used multiple testing procedures. Comparison of different approaches as applied to gene expression data. METHODS This article focuses on familywise error rate (FWER) and false discovery rate (FDR) controlling procedures. Methods under investigation include: Bonferroni-type methods and...

When I was doing my Masters degree in Information Science, quite a number of years ago, the idea that the things I and my fellow students were studying were of relevance to everyday life would have seemed strange to us. We were dealing with ways of providing formal published information to academics and professionals; 'scholarly communication' was the name of the game. True, we were aware of pu...

Cerebral cortex Cognitive behavioural therapy (CBT) assumes that those who are reasonably reasonable most of the time have more pleasant emotional lives. “The wise man is always happy—keeping an eye on his logic,” wrote Cicero, the prefeminist philosopher. Today even the Dalai Lama favours rationality: “My experience is that [mental peace] is obtained mainly through reasoning. Meditation does n...

BACKGROUND In recent years, analyses of event related potentials/fields have moved from the selection of a few components and peaks to a mass-univariate approach in which the whole data space is analyzed. Such extensive testing increases the number of false positives and correction for multiple comparisons is needed. METHOD Here we review all cluster-based correction for multiple comparison m...