Mailing address: Gabriel Antonio Stanisci Miguel • Rua Santa Madalena, 290/131 01322-020 São Paulo, SP Brazil E-mail: [email protected] Manuscript received November 13, 2006; revised manuscript received February 16, 2007; accepted March 13, 2007. We treated a 37-year old male patient with diagnosis of poor left ventricle compaction. The two-dimensional echocardiography demonstrated extensive...

3D printing is expected to revolutionize health care through uses in tissue and organ fabrication; creation of customized prosthetics, implants, and anatomical models; and pharmaceutical research regarding drug dosage forms, delivery, and discovery.

Our face is our password—face recognition promises to revolutionize the way we identify individuals in a nonintrusive and convenient manner. Even though research in face recognition has spanned over nearly three decades, only 2D systems, with limited adoption to practical applications, have been developed so far. The primary reason behind this is the low accuracy of 2D face recognition systems ...

Elevated overexpression of the lncRNA HOTAIR mediates invasion and metastasis in breast cancer. In an apparent paradox, we observed low expression of HOTAIR in the invasive Claudin-low MDA-MB-231 and Hs578T cells in two-dimensional culture (2D). However, HOTAIR expression exhibited robust induction in laminin-rich extracellular matrix-based three-dimensional organotypic culture (lrECM 3D) over ...

Researchers are turning to three-dimensional (3D) cell culture as a way to increase the biological relevance of their disease models and predictive value of drug studies1. These 3D models typically increase the level of cell-cell interaction and reduce or eliminate the dominant cell-plastic interaction seen in standard monolayer cultures. There are a number of ways of generating 3D cell culture...

DNA damage and consequent mutations initiate the multistep carcinogenic process. Differentiated cells have a reduced capacity to repair DNA lesions, but the biological impact of unrepaired DNA lesions in differentiated lung epithelial cells is unclear. Here, we used a novel organotypic human lung three-dimensional (3D) model to investigate the biological significance of unrepaired DNA lesions i...

Alginate, a non-toxic polysaccharide isolated from brown algae, is a widely used 3-dimensional (3D) porous scaffold for the granulosa cell and follicle encapsulation. However, impurities in commercial alginate can lead to alginate biocompatibility reduction. The aim of this study was to evaluate in vitro behavior of the granulosa cells seeded on the purified alginate in varying concent...

Multimaterial 3D printing using microfluidic printheads specifically designed for seamless switching between two visco-elastic materials "on-the-fly" during fabrication is demonstrated. This approach opens new avenues for the digital assembly of functional matter with controlled compositional and property gradients at the microscale.