The anticoagulant effect of apixaban is due to direct inhibition of FXa in the coagulation cascade. The main advantages apixaban has over the current anti-coagulant drugs is that it is active after oral administration, and its coagulation effect does not require monitoring. Apixaban has been compared to enoxaparin in the prevention of venous thromboembolism associated with knee and hip replacem...

The risk of stroke is increased 4to 5-fold in patients with atrial fibrillation (AF). Predicting this risk is a significant clinical challenge. Despite the knowledge that most thrombi leading to cerebral embolization arise in the left atrial appendage (LAA), physicians today rely heavily on clinical predictors (CHADS2 [congestive heart failure, hypertension, age Z75 y, diabetes mellitus, and pr...

Guidelines recommend thromboprophylaxis for at least 10 days to prevent venous thromboembolism in patients undergoing high-risk orthopedic surgery, such as total hip arthroplasty (THA) or total knee arthroplasty (TKA). Furthermore, the recently updated ACCP guidelines also recommend extending the duration of thromboprophylaxis for 28 to 35 days following THA or hip fracture surgery as the risk ...

BACKGROUND Patients who have had a first episode of unprovoked venous thromboembolism have a high risk of recurrence after anticoagulants are discontinued. Aspirin may be effective in preventing a recurrence of venous thromboembolism. METHODS We randomly assigned 822 patients who had completed initial anticoagulant therapy after a first episode of unprovoked venous thromboembolism to receive ...

Thromboembolism is a clinical finding that occurs due to thrombus; formed in the vascular system and has various etiological factors. It can be classified as central peripheral thromboembolism. Our objective this study explore genetic risk factors thromboembolism reveal differences. 342 patients were retrospectively included between January 2016 December 2019. Demographic characteristics, for m...

The CHA2DS2-VASc scale is commonly used to assess the risk of thromboembolism in patients with atrial fibrillation (AF). Oral anticoagulants are recommended for prevention stroke AF a score ≥ 2 men and 3 women. There known factors that have not been included this scale, but they significantly increase thromboembolism. Not all who at high receive anticoagulation therapy. This mainly due contrain...

Thromboembolism is a rare complication of primary nephortic syndrome. Both venous and arterial thrombosis might occur in steroid responsive and steroid resistant nephrotic syndrome. This is the report of an infant with nephrotic syndrome and renovascular hypertension, complicated with asymptomatic intracardiac thrombus and managed appropriately with medical treatment.

OBJECTIVE High baseline YKL-40 is associated with later development of ischemic stroke, but not with myocardial infarction. Whether high YKL-40 levels are associated with increased risk of venous thromboembolism is presently unknown. We tested the hypothesis that observationally and genetically high YKL-40 is associated with increased risk of venous thromboembolism in the general population. ...

Advanced cancer is a risk factor for venous thromboembolism. However, lymph node metastases are usually not considered an established risk factor. In the framework of the prospective, observational Vienna Cancer and Thrombosis Study we investigated the association between local (N0), regional (N1-3), and distant (M1) cancer stages and the occurrence of venous thromboembolism. Furthermore, we we...