Pulmonary embolism is a common condition leading to significant morbidity and mortality. Standard initial therapy consists of heparin treatment, which has been shown to improve the outcome. Nevertheless, 3-month mortality remains high, ranging from 10% to 17.5%, and is higher for massive PE. Thrombolysis for acute PE remains a controversial treatment, due in part to the inadequate evidence demo...

BACKGROUND AND PURPOSE Thrombolysis in patients >80 years remains controversial; we hypothesized that >80-year-old patients with wake-up ischemic stroke (WUIS) will benefit from thrombolysis despite risks because of poor outcomes with no treatment. METHODS The study included 68 thrombolysed patients with WUIS (33 [48%] >80 years), 54 nonthrombolysed patients with WUIS (21 [39%] >80 years), an...

Hypothesis: Predictive strength of each predictor of successful thrombolysis is different. There is diurnal variation in the efficacy of streptokinase thrombolysis. Methodology: Retrospective study. 34 consecutive patients treated with streptokinase.ed retrospectively; success or failure of thrombolysis was determined according to accepted clinical and ECG criteria. Results: The mean age of the...

The authors compared the transcranial color-coded duplex pattern of the middle cerebral arteries (MCAs) before and after IV and combined IV-intra-arterial (IV-IA) thrombolysis in consecutive first-ever stroke patients. Patients receiving combined IV-IA thrombolysis showed greater improvement in flow signal and higher incidence of complete MCA recanalization vs those receiving IV thrombolysis, e...

OBJECTIVES This study was designed to test the hypothesis that the level of aortic blood pressure affects the rate and extent of coronary thrombolysis induced by intracoronary administration of recombinant tissue-type plasminogen activator (rt-PA). BACKGROUND Although many studies have confirmed the efficacy of thrombolytic therapy in the treatment of acute myocardial infarction, the effects ...

BACKGROUND AND PURPOSE Thrombolysis for acute ischemic stroke in the elderly population is seldom administered. METHODS In this study, we evaluated the risks of thrombolysis, including the mortality and intracerebral hemorrhage (ICH) rates in this population. A cohort of patients was identified from the National Inpatient Sample database for the years 2000-2006. Age was categorized in 2 group...

BACKGROUND AND AIM Intravenously-administered tissue plasminogen activator (IV-TPA) induces thrombolysis and remains the only FDA-approved therapy for acute ischaemic stroke. IV-TPA thrombolysis has been approved recently in Singapore for acute stroke. Continuous exposure of clot to 2-MHz pulsed-wave transcranial Doppler (TCD) ultrasound during IV-TPA infusion is known to augment thrombolysis. ...

Introduction: Acute pulmonary embolism (PE) is one of the deadly cardiovascular diseases. One of the indexes proposed in these patients for risk stratification is the Thrombolysis in Myocardial Infarction (TIMI) risk index (TRI), which includes three parameters of systolic blood pressure, age, and heart rate. This study aimed to evaluate the predictive value of TRI on in-hospit...

There is increasing evidence that local thrombolysis can be used with relative safety and efficacy in adults with superior sagittal sinus thrombosis (SSST). However, little data is available on the use of local thrombolysis in children with SSST. We report three patients who received local thrombolysis for dural sinus thrombosis. Two patients received urokinase and one patient received urokinas...

IMPORTANCE The effectiveness of intravenous thrombolysis in acute ischemic stroke is time dependent. The effects are likely to be highest if the time from symptom onset to treatment is within 60 minutes, termed the golden hour. OBJECTIVE To determine the achievable rate of golden hour thrombolysis in prehospital care and its effect on outcome. DESIGN, SETTING, AND PARTICIPANTS The prospecti...