Background & objective: papillary thyroid cancer is the most common cancer of thyroid accounting for 75%-85% of all thyroid malignancies. Recently, β-catenin has been determined to play a role in clinical course of human epithelial cancers. This study was designed to reveal the association of β-catenin marker and papillary thyroid carcinoma behavior.<b...

Bayesian hierarchical models are built to fit multiple health endpoints from a dose-response study of a toxic chemical, perchlorate. Perchlorate exposure results in iodine uptake inhibition in the thyroid, with health effects manifested by changes in blood hormone concentrations and histopathological effects on the thyroid. We propose linked empirical models to fit blood hormone concentration a...

BACKGROUND Perchlorate is an environmental contaminant that blocks iodine uptake into the thyroid gland and reduces thyroid hormones. This action of perchlorate raises significant concern over its effects on brain development. OBJECTIVES The purpose of this study was to evaluate neurologic function in rats after developmental exposure to perchlorate. METHODS Pregnant rats were exposed to 0,...

Distant metastases are a rare occurrence in differentiated thyroid cancer, and when detected in skin, often arise in the context of disseminated disease after many years of progression since diagnosis. This study presents the case of a 77-year-old female without known thyroid disease, who presented with metastases in the parieto-occipital scalp region, in which thyroid tissue was identified. Th...

INTRODUCTION Riedel's thyroiditis is a rare thyroid disease characterized by dense fibrous tissues that replace the thyroid gland and invade the adjacent structures that can mimic thyroid malignancy. We discuss the presentation, investigation and management of this very rare condition. CASE PRESENTATION We present a case of a 59-year-old African-Caribbean man who presented with a rapidly grow...

OBJECTIVES The majority of childhood cancer patients now achieve long-term survival, but the treatments that cured their malignancy often put them at risk of adverse health outcomes years later. New cancers are among the most serious of these late effects. The aims of this review are to compare and contrast radiation dose-response relationships for new solid cancers in a large cohort of childho...

Iodine-131 (131I) plays an important role in the management of patients with well-differentiated thyroid cancers. Post-thyroidectomy ablation therapy with 131I is performed to destroy the small amount of thyroid tissue remaining in the neck after surgery [8,14]. The use of radioiodine for ablation has been shown to decrease the risk of recurrence, increase the sensitivity of post-ablation whole...

Radioiodine and natural iodine are chemically and physiologically identical, providing the former is present in quantities so small as to be without biologic effects due to radiation per se. A minute quantity of radioiodine may be used to trace, by its radioactivity, the course of a given quantity of iodine through various chemical and biologic reactions. Hertz (1, 2) was the first to call atte...

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) affects the thyroid morphologically and/or functionally in adult animals. Recently, the National Toxicology Program conducted a 2-year gavage study of TCDD in female Harlan Sprague-Dawley rats. The only treatment-related alterations found in thyroid follicles were decreased luminal size and increased height of the follicular epithelial cells, without p...

Objective: The current work was conducted to study the disease status and treatment results of patients with differentiated thyroid carcinoma referred for surgery and for radioactive iodine therapy. Methods: Retrospective review of 174 patients with differentiated thyroid carcinoma referred for surgery and for radioactive iodine therapy in King abulaziz Hospital and Oncology Center, Jeddah, Sau...