Background and purpose: Radiomics features are used to identify disease types predict therapy outcomes. However, how the radiomics different among anatomical structures has never been investigated. Hence, we analyzed of 22 in head neck area CT images. Furthermore, studied whether can classify using unsupervised machine-learning techniques. Materials methods: We obtained IMRT/VMAT treatment plan...

FLIP is an antiapoptotic protein that has been demonstrated to play an important role in inflammation, cancer, and autoimmune diseases. However, it is not known whether increased expression of FLIP (FLICE inhibitory protein) in thyrocytes would alter the development of the thyroid and/or pathogenesis of thyroiditis. To examine the effects of overexpression of this antiapoptotic molecule on the ...

OBJECTIVE Thyroid proteomics is a new direction in thyroid cancer research aiming at etiological understanding and biomarker identification for improved diagnosis. METHODS Two-dimensional electrophoresis was applied to cytosolic protein extracts from frozen thyroid samples (ten follicular adenomas, nine follicular carcinomas, ten papillary carcinomas, and ten reference thyroids). Spots with d...

When CD4+ CD25+ regulatory T cells are depleted or inactivated for the purpose of enhancing antitumor immunity, the risk of autoimmune disease may be significantly elevated because these regulatory T cells control both antitumor immunity and autoimmunity. To evaluate the relative benefit and risk of modulating CD4+ CD25+ regulatory T cells, we established a new test system to measure simultaneo...

Emerging evidence suggests cancer stem cells (CSCs) may initiate new tumors in anaplastic thyroid carcinoma (ATC), one of the most aggressive solid tumors in humans. However, the involvement of CSCs in human tumorigenesis has not been previously studied in authenticated ATC cell lines. Here we demonstrate a functional role of CSCs in four new validated human ATC cell lines (THJ-11T, THJ-16T, TH...

Dog thyroids and guinea pig eyes Judah Folkman’s radical idea began with a mundane task. In 1961, Folkman, then a third year surgical resident, was drafted by the navy and charged with optimizing the use of freeze-dried hemoglobin as an alternative to fresh blood. The hemoglobin preparations were tested for the ability to sustain the viability of dog thyroid glands and, later, the growth of mou...

o^noma of the thyroid is uncommon. In the South-West Region it accounts for per 0'fy) per cent of all cancer, (excluding that of the skin). This compares with 0-4 this Cent of a total of some 447,000 deaths from cancer (excluding the skin) notified in l?0Q6?Un.try between 195I and 1955.1 In the Bristol Royal Infirmary since 1950, an j Patients with enlarged thyroids have been seen, and of these...