We have studied the beneficial effects of a hydroxyapatite (HA) coating on the prevention of the migration of wear debris along the implant-bone interface. We implanted a loaded HA-coated implant and a non-coated grit-blasted titanium alloy (Ti) implant in each distal femoral condyle of eight Labrador dogs. The test implant was surrounded by a gap communicating with the joint space and allowing...

the aim of this study was to investigate the sol gel synthesis of ha/fa nanoparticles and the possible formation of tcp phase or unstoichiometric calcium deficient hydroxyapatite (cdha) from the precursors with a ca/p ratio of 1.62. in order to prepare the sol, the solutions of triethyl phosphite, ammonium fluoride and calcium nitrate in ethanol were used respectively as p, f and ca precursors....

Since the 1980s, titanium (Ti) implants have been routinely used to replace missing teeth. This success is mainly due to the good biocompatibility of Ti and the phenomenon of osseointegration, with very early events at implant placement being important in determining good osseointegration. However, enhancing implant performance with coatings such as hydroxyapatite (HA) and calcium phosphate has...

We report here, for the first time, a novel multi-scaled hybrid orthopedic implant material consisting of a macroporous Ti scaffold, whose macropores' walls have a microporous titania layer which is fully covered with nanofibers of Sr-doped hydroxyapatite (Sr-HA). The microporous titania layer is formed on and within the Ti scaffold by micro-arc oxidation, which firmly binds to the Ti substrate...

Osteoblasts respond to microarchitectural features of their substrate. On smooth surfaces (tissue culture plastic, tissue culture glass, and titanium), the cells attach and proliferate but they exhibit relatively low expression of differentiation markers in monolayer cultures, even when confluent. When grown on microrough Ti surfaces with an average roughness (Ra) of 4-7 mum, proliferation is r...

Plasma electrolytic oxidation (PEO) is proven as a scalable method for surface treatment of titanium (Ti) providing thick oxide layer with porous micro-nano morphology. Despite the lack antibacterial performance, this modification has potential to improve osseointegration properties Ti-based implant. To address limitation, we demonstrated new concept, showing that partial incorporation graphene...

Titanium is widely used in biomedical materials, particularly in dental implants, because of its excellent biocompatibility and mechanical characteristics. However, titanium implant failures still remain in some cases, varying with implantation sites and patients. Improving its overall performance is a major focus of dental implant research. Equal-channel angular pressing (ECAP) can result in u...

objective(s):   the production of nano-hydroxyapatite by two encapsulated bacterial strains was the goal of current research.  materials and methods:   serratia marcscens atcc 14756 and pseudomonas aeruginosa ptcc 1570 were used by two methods including encapsulated form in 2% (w/v) alginate sodium powder and inoculated form (10%) in nutrient broth medium containing alginate sodium blank beads....

OBJECTIVE In this study, the authors assessed the ability of rat bone marrow derived mesenchymal stem cells (BMDMSCs), in the presence of a growth factor, fibroblast growth factor-4 (FGF-4) and hydroxyapatite, to act as a scaffold for posterolateral spinal fusion in a rat model. METHODS Using a rat posterolateral spine fusion model, the experimental study comprised 3 groups. Group 1 was compo...

The enhanced catalytic activity of permanently polarized hydroxyapatite, which is achieved using a thermally stimulated polarization process, largely depends on both the experimental conditions used to prepare crystalline hydroxyapatite from its calcium and phosphate precursors process parameters. A mineral similar brushite, an apatitic phase that can evolve found at surface highly hydroxyapati...