BACKGROUND Primarily safe and efficacious treatments for chronic tic disorders are needed. Also needed are such treatments that target co-morbid conditions. Aripiprazole, a dopaminergic/serotonergic agent with partial agonist properties at the D2 dopamine receptor and 5-hydrdoxytryptamine 1A (5-HT(1A)) receptor and antagonist properties at the 5-HT(2A) receptor, holds promise in both regards. ...

Aluminum matrix composites (AMCs), reinforced with ceramic particulates, have significant applications in the field of aerospace, marine, automobiles, sports and recreation. Al-TiC particulate composite has better potential for high-temperature applications. The corrosion behaviour of Al 6061-TiC particulate composites prepared by stir casting route, has been explored in chloride medium using e...

OBJECTIVE The purpose of this study was to investigate whether the presence of tic disorder is negatively associated with sertraline (SRT) outcomes, but not with continued cognitive-behavioral therapy (CBT), in a sample of youth who were unresponsive to an initial full course of CBT. METHODS In the Nordic Long-Term OCD Study, children and adolescents with OCD who were rated as nonresponders t...

This study focuses on the fabrication and microstructural investigation of Cu–TiH2–C and Cu–Ti–C nanocomposites with different volume fractions (10% and 20%) of TiC. Two mixtures of powders were ball milled for 10 h, consequently consolidated by spark plasma sintering (SPS) at 900 and 1000 ◦C producing bulk materials with relative densities of 95–97%. The evolution process of TiC formation duri...

BACKGROUND Human fetal prostate buds appear in the 10th gestational week as solid cords, which branch and form lumens in response to androgen 1. Previous in vivo analysis of prostate epithelia isolated from benign prostatectomy specimens indicated that Epcam⁺ CD44⁻ CD49f(Hi) basal cells possess efficient tubule initiation capability relative to other subpopulations 2. Stromal interactions and b...

Background: Obsessive-compulsive disorder (OCD) symptoms and the related disorders are subsumed under chronic psychiatric disorders which are of psychosocial and therapeutic importance. In most studies, the mean age of onset of significant OCD symptoms is adolescence period. The aim of this study was to evaluate OCD symptoms, Tic disorder, Body Dysmorphic Disorder (BDD) and Trichotilomania amon...

Purpose: Cancer recurrence is one of the major setbacks in oncology. Maintaining telomeres is essential for sustaining the limitless replicative potential of such cancers. Because telomerase is thought to be active in all tumor cells and normal stem cells, telomerase inhibition may be nonspecific and have detrimental effects on tissue maintenance and development by affecting normal stem cell se...