Aims Bone fracture risk analysis is a mandatory issue for the prevention of traumatic events and the reduction of medical efforts. The standard analysis for the evaluation of bone fracture risk is the analysis of Bone Mineral Density (BMD) [1, 2]. However, using only BMD to predict bone fracture risk was demonstrated to be not reliable [3]. This is probably due to the role of morphology in bone...

The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...

The emergence of complex shapes during the development of plants is under the control of genetically determined molecular networks. Such regulatory networks, comprising hormones and transcription factors, regulate the collective behavior of cell growth within a tissue. Because all the cells within a tissue are linked together by the cell wall, their collective growth generates a good amount of ...

All cells sense and integrate mechanical and biochemical cues from their environment to orchestrate organismal development and maintain tissue homeostasis. Mechanotransduction is the evolutionarily conserved process whereby mechanical force is translated into biochemical signals that can influence cell differentiation, survival, proliferation and migration to change tissue behavior. Not surpris...

Advanced glycation end-products (AGE) contribute to age-related connective tissue damage and functional deficit. The documented association between AGE formation on collagens and the correlated progressive stiffening of tissues has widely been presumed causative, despite the lack of mechanistic understanding. The present study investigates precisely how AGEs affect mechanical function of the co...

Although subcutaneous adipose tissue undergoes large deformations on a daily basis, there is no adequate mechanical model to describe the transfer of mechanical load from the skin throughout the tissue to deeper layers. In order to develop such a non-linear model, a set of experimental data is required. Accordingly, this study examines the long term behavior of adipose tissue under small strain...

In surgical training applications and experimental research, brain tissues immersed in cerebrospinal fluid often involve very complex deformation strain rate effects, which affects their reliability stability. Thus, it is indispensable to develop a high-fidelity human tissue simulant material as physical surrogate model understand mechanical behavior, such traumatic injury (TBI). However, the r...