A de novo peptide that self-assembles into fibrillar structures and serves as a substrate for the cross-linking enzyme tissue transglutaminase was developed (Ac-QQKFQFQFEQQ-Am). Congo red staining, circular dichroism, and FTIR spectroscopy showed that this 11-amino acid peptide produced predominantly beta-sheet structures. TEM with negative staining and quick-freeze deep etch (QFDE) TEM showed ...

background: celiac disease is one of the malabsorption syndromes leads to growth and development retardation in children. there is no test lonely can definitely diagnose celiac; however, the collection of clinical findings, serologic tests, intestinal biopsy, and response to treatment may diagnose it. although diagnostic value is variable in different studies, they are used a non-invasive and a...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: the prevalence of irritable bowel syndrome (ibs) in the community is 10%–20% and have symptom based diagnostic criteria. many symptoms of celiac disease (cd) with 1% prevalence in some communities can mimic ibs. sensitive and specific serologic tests of cd can detect asymptomatic cases. the purpose of this stud...

The culture of peritoneal macrophages in serumcontaining media induces a dramatic increase in the expression of the enzyme tissue transglutaminase. The transglutaminase-inducing activity of serum is abolished by extraction of lipids and fully restored by readdition of physioIogica1 concentrations (1-100 nM) of truns-retinoic acid. Induction of the enzyme is detectable within a 90-min exposure o...

BACKGROUND Individuals with active celiac disease (CD+) have an increased incidence of thyroid dysfunction, which improves on a gluten-free diet (CD-). We investigated whether tissue transglutaminase-2 IgA antibodies (anti-TGase II) present in sera of patients with celiac disease react with thyroid tissue and possibly contribute to thyroid disease. METHODS Serum from 40 active celiac patients...

Transglutaminases are a group of enzymes that catalyze the covalent conjugation of amines to protein-bound glutamine residues. The products of transglutaminase activity are proteins covalently cross-linked by ~-(3"-glutaminyl)-lysine isopeptide bonds and proteins containing covalently conjugated polyamines (16). Several distinct intracellular and extracellular transglutaminases have been identi...

Abstract Introduction Celiac disease (CD) is highly prevalent in patients with type 1 diabetes mellitus (T1DM). However, the rate of CD Syrian children and adolescents T1DM unknown. We aimed to investigate prevalence characteristics our unprivileged rural community. Methods Children who were regularly followed a private endocrine clinic Raqqa City, Syria, evaluated from October 2018 November 20...