Prilocaine and lidocaine are classified as amide-type local anesthetics for which serious adverse effects include methemoglobinemia. Although the hydrolyzed metabolites of prilocaine (o-toluidine) and lidocaine (2,6-xylidine) have been suspected to induce methemoglobinemia, the metabolic enzymes that are involved remain uncharacterized. In the present study, we aimed to identify the human enzym...

Background and aim: Antimicrobial photodynamic therapy (aPDT) has been suggested as a novel technique for decontamination of exposed implant surfaces. We aimed to evaluate the effect of aPDT on sandblasted, large-grit, acid-etched (SLA) titanium discs contaminated with Eikenella corrodens (Ec) and Aggregatibacter actinomycetemcomitans (Aa). Materials and methods: In this in-vitro study, twenty...

The generation of methaemoglobin is a rare but potential life-threatening side effect in the use of the local anaesthetic prilocaine. It is currently only possible to ensure the diagnosis by means of blood tests. Rapid noninvasive diagnosis is desirable, especially for risk patients. Using a pig model, we induced methaemoglobinemia via application of dimethyl aminophenol and prilocaine (setup I...

BACKGROUND Methamphetamine (MA) was shown to have harmful effects on male reproductive system. OBJECTIVE To investigate probable effects of daily administration of MA on sperm parameters and chromatin/DNA integrity in mouse. MATERIAL AND METHODS Thirty-five NMRI male mice were divided into five groups including low, medium, and high dosage groups which were injected intraperitoneally with 4...

Synthesis of zeolite from kaolinite clay is a very promising process, requiring thorough beneficiation and calcinations to obtain purer monomer. Kaolinite clay sourced from Kankara, Nigeria is associated with inherent impurities, making its transformation rather challenging. The addition of dye, though, assisted in inhibiting the negative effects of impure phases on the desired end products and...

The staining properties of tissue mast cells are influenced by the method of fixation. Differences in fixation and staining techniques may explain the contradictory results in the published reports on the number of human mucosal mast cells (MMC) in the gastrointestinal mucosa in health and disease. We have examined the influence of fixatives on the staining properties of human MMC in operative ...

Introduction: We report an elderly gentleman with Extramammary Paget’s disease (EMPD) treated Mohs micrographic surgery (MMS) using Toluidine blue staining intraoperatively as to detect the cells. Case Presentation: An man presented erythematous plaque on left inguinal fold which showed in-situ EMPD histopathological examination. Investigations for secondary were negative and patient was MMS. D...