22 23 24 Combined systemic and topical administration of voriconazole have been successfully used to 25 treat keratomycosis infection. No voriconazole eye drop product being commercially 26 available, we prepared a sterile eye drop solution (10 mg/ml). Voriconazole remains stable 27 over 30 days providing an eye drop solution suitable for topical treatment of fungal keratitis. 28 29 30 31 32 33...

Topical ophthalmic instillation is an appealing strategy to deliver drugs the back of eye treat retinal diseases such as neovascular age-related macular degeneration, diabetic retinopathy, vein occlusion, and glaucomatous optic neuropathy. It has several advantages being non-invasive user-friendly, e.g., allowing self-administration. However, main obstacle been how achieve therapeutic drug conc...

Aims—To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration. Methods—31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received combined administration. Collected SRF samples were anal...

Breakthrough seizures are often encountered in patients with well-controlled epilepsy for no obvious reason. We report a case of a breakthrough seizure after temporal lobectomy secondary to topical administration of essential oils. We recommend inquiring about the use of essential oils in patients with well-controlled epilepsy who experience breakthrough seizures.

Here we demonstrated that SKI2162, a small-molecule inhibitor of the TGF-β type I receptor (ALK5), prevented radiation-induced fibrosis (RIF) in mice. SKI2162 inhibited phosphorylation of Smad and induction of RIF-related genes in vitro. In RIF a mouse model, SKI2162 reduced late skin reactions and leg-contracture without jeopardizing the acute skin reaction. Irradiation of mouse tissue increas...

Eye is second most complex organ of the body after brain. Drug delivery to the eye is the challenging task for the pharmaceutical scientists. Topical administration to the eye is the most convenient and commonly used for the pharmacological therapy. Effectiveness of the drugs can only be determined by the pharmacokinetics and pharmacodynamics correlation. Ocular pharmacokinetics is the essentia...