Foreign women account for 12% of births in France, andimmigrant women, including naturalized French citizens,15%. The fertility of foreign women is higher than that ofFrench women (3.3 children versus 1.8 in 2004), but sinceonly a small minority of the population is concerned, theeffect on overall fertility is minimal. These extra birthsincreased the fertility rate o...

OBJECTIVE To test whether there is an association between abortion legislation and maternal mortality outcomes after controlling for other factors thought to influence maternal health. DESIGN Population-based natural experiment. SETTING AND DATA SOURCES Official maternal mortality data from 32 federal states of Mexico between 2002 and 2011. MAIN OUTCOMES Maternal mortality ratio (MMR), MM...

The dynamic relationship between constitutive and ligand-triggered clathrin-mediated endocytosis is only poorly characterized, and it remains controversial whether clathrin-coated pits specialize to internalize particular receptor cargo. Here we analyzed the ligand-triggered endocytosis of the model G-protein-coupled receptors (GPCRs) β2-adrenergic receptor (β2AR) and Mu-opioid receptor (MOR) a...

Cell-surface receptors that undergo clathrin-mediated endocytosis contain short amino acid sequences in their cytoplasmic domain that serve as internalization signals. Interactions between these sequences and components of the endocytic machinery should become limiting upon overexpression of the constitutively recycling transferrin receptor (TfR). A tetracycline-responsive system was used to in...

A complication of total femoral replacement (TFR) is periprosthetic infection. Studies have shown that infected endoprostheses have a significant amputation rate, as high as 36.7%. This study examined possible risk factors that may attribute to unsalvageable TFRs following periprosthetic infections, including age, sex, primary vs secondary TFRs, number of irrigation and debridements, recent his...

BACKGROUND The effects of socio-economic factors on suicide were gender-dependent. Japanese suicide mortality gender ratio (male: female) had gradually increased during the twentieth century. METHODS With the data covering 1947-2010 collected from Japanese official websites, we conducted non-parametric rank test, curve estimations, spearman ranking correlation and quantile regression in succe...

What we will call the age-based TMFR is computed conventionally by adding up agespecific marital-fertility rates in the hope of estimating the number of children ever born to a woman who is married throughout her childbearing years. Demographers have long been strongly skeptical about this quantity because it normally indicates implausibly many children. Our analysis of data from the Romanian G...

T cell receptor engagement by an APC induces the formation of a highly organized complex of surface receptors and intracellular signaling molecules, known as the immunological synapse, at the site of cell-cell contact. The transferrin receptor (TfR, CD71) is normally present in the plasma membrane and recycling endosomes. In this study, we show that, although the TfR is typically absent from li...

Introduction Despite being one of the countries that has enjoyed relative peace for a sufficiently long time, Malawi remains one of the countries in the world with the worst health indicators. The maternal mortality rate for Malawi is very high by any standard. According to the Malawi Demographic and Health Surveys (MDHS), the maternal mortality rate for Malawi almost doubled between 1992 (620 ...