Toxic neuropathies generally result in length dependent axonal neuropathy with the exception of diphtheria and a few toxic neuropathies. In spite of occurrence of diphtheria in India there is paucity of published reports on diphtheritic neuropathy. Arsenic neuropathy commonly occurs in Bengal and Bangladesh because of ground water contamination whereas in Punjab it is due to contamination of op...

If you have a problem, no matter how large or small, Current Biology's 'agony aunt' Amber can help. Dear Amber, I pioneered a wonderful, elegant technique that everyone used, and for a while they all looked up to me. Now, a new method has superseded mine, and I'm no longer considered important. What can I do? Dear Technical, Rejoice, science has progressed. It's left you behind, and that's too ...

Bacillus subtilis possesses a secondary transporter CitM that is specific for the complex of citrate and Mg but is also capable of transporting citrate in complex with the heavy metal ions Zn, Ni and Co. We report on the impact of CitM activity on the toxicity of the heavy metals Zn, Ni and Co + in B. subtilis. In a CitM deletion mutant or under conditions when CitM is not expressed, the toxic ...

heart failure (hf) is a common disease with high health care costs and high mortality rate knowledge of the health-related quality of life (qol) outcomes of hf may guide decision making and be useful in assessing new therapies for population. yet little is known about qol of hf patients in iran. objectives: to assess health related qol of patients with hf with two different instrument and to co...

Direct estimation of species' tolerance to pesticides and other toxic organic substances is a combinatorial problem, because of the large number of species-substance pairs. We propose a statistical modelling approach to predict tolerances associated with untested species-substance pairs, by using models fitted to tested pairs. This approach is based on the phylogeny of species and physico-chemi...

Furan is a liver toxicant and carcinogen in rodents. Although humans are most likely exposed to furan through a variety of sources, the effect of furan exposure on human health is still unknown. In rodents, furan requires metabolism to exert its toxic effects. The initial product of the cytochrome P450 2E1-catalyzed oxidation is a reactive a,b-unsaturated dialdehyde, cis-2-butene-1,4-dial (BDA)...