Multiple independent adeno-associated virus (AAV) gene therapy clinical trials for hemophilia B, utilizing different AAV serotypes, have reported a vector dose-dependent loss of circulating factor IX (FIX) protein associated with capsid-specific CD8+ T cell (Cap-CD8) elimination of transduced hepatocytes. Hemophilia B patients who develop transient transaminitis and loss of FIX protein may be s...

INTRODUCTION Enteric fever is a common infection in endemic areas; however, there are few reports describing the computed tomography (CT) manifestations of enteric fever. We aim to describe and illustrate CT findings in enteric fever in this study. MATERIALS AND METHODS A retrospective search of medical records in our institute for patients with positive blood cultures for Salmonella typhi, a...

Drugs are a significant cause of liver injury. Drug-induced liver injury (DILI) can cause acute hepatitis, cholestasis, or a mixed pattern. Ceftriaxone is a commonly used antibiotic and has been associated with reversible biliary sludge, pseudolithiasis, and cholestasis. A 32-year-old male with sickle cell disease was admitted to the hospital for acute sickle cell crisis. On the second day of h...

Case report A 63 year old lady presented to a peripheral centre polyarthralgia, multiple tender and erythematous nodules over her face, elbows, back and legs and continuous fever of 2 months duration. Routine investigations being negative, she was referred for further evaluation of PUO. On presentation, the patient was febrile. Apart from the nodules, examination revealed bilaterally thickened ...

Background: In poor countries, typhoid fever is a major cause of fever. The illness can vary in severity from an uncomplicated febrile to sepsis and complications like hemophagocytic lymphohistiocytosis (HLH), which affects multiple organs. A delay diagnosis frequently the biggest obstacle good outcome due rarity this syndrome. Case: 38-year-old male was admitted with complaints persistent inte...

Introduction: Standard therapies for most relapsed/refractory (R/R) T-cell lymphomas (TCL) have overall response rates (ORR) of 25%-35%. Phosphoinositide-3-kinase (PI3K) ? and ? isoforms can promote tumor cell autonomous nonautonomous effects in TCL. Initial studies the PI3K-?/? inhibitor duvelisib (D) R/R TCL showed an ORR 50% CR 19%, but also a 40% rate grade (Gr) 3/4 ALT elevation at MTD 75 ...

Abstract Introduction: FLT180a (verbrinacogene setparvovec) is an investigational, liver-directed AAV gene therapy for the treatment of patients with hemophilia B (HB). consists a novel, potent, engineered capsid (AAVS3) containing expression cassette encoding Factor IX (FIX) gain-of-function protein variant ('Padua'; FIX-R338L). The B-AMAZE study was designed to identify dose that maintains FI...

Background and aim: Hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) is traditionally considered a contraindication for liver transplantation (LT). Successful downstaging has been shown to improve survival. Limited data have promising results the use of immune check point inhibitor like nivolumab downstage these patients transplantation. The novel combination checkpoint atezoliz...

Background/Aim. The availability of thrombopoietin receptor agonists (TPO-RA) for treating primary immune thrombocytopenia (ITP) has transformed its management over the last decade. aim this study was to assess efficacy TPO-RA in adults with chronic ITP treated at University Clinical Center Serbia. Methods. A total 28 adult patients ( 10 m ales and 18 females), who were given eltrombopag and/or...

Ecteinascidin 743 (ET-743) is a cytotoxic tetrahydroisoquinoline alkaloid that covalently binds to DNA in the minor groove. The in vitro chemosensitivity of cancer cells to ET-743 is markedly enhanced by prolonging the duration of exposure to the drug. A Phase I study of ET-743 given as a 72-h continuous i.v. infusion every 21 days was performed. Characteristics of the 21 adult patients with re...