DNA double-strand breaks (DSBs) are toxic lesions triggered not only by environmental sources, but also a large number of physiological processes. Of importance, endogenous DSBs frequently occur in genomic loci that transcriptionally active. Recent work suggests occurring transcribed handled specific pathway(s) entail local transcriptional repression, chromatin signaling, the involvement RNA sp...

Abstract We have previously shown that the transmembrane protein ODZ1 serves for glioblastoma (GBM) cells to invade surrounding tissue through activation of RhoA/ROCK pathway. However, transcriptional machinery used by GBM regulate expression is unknown. Here we show interaction with tumor microenvironment elements, mainly activated monocytes IL-6 secretion, and extracellular matrix fibronectin...

Esophageal cancer (ESCA) is one of the highest lethal malignancy tumors worldwide. Baculoviral IAP repeat-containing protein 3 (BIRC3) main inhibitor apoptosis in many malignancies. The aim this study was to clarify how BIRC3 acts ESCA cells. Through TNMplot and GEPIA2 analysis, found abundantly expressed quantitative RT-PCR assay confirmed pronouncedly induced all used cell lines. In addition,...

The connection between genotype and phenotype was assessed by determining the adhesion phenotype for the same mutation in two closely related yeast strains, S288c and Sigma, using two identical deletion libraries. Previous studies, all in Sigma, had shown that the adhesion phenotype was controlled by the filamentation mitogen-activated kinase (fMAPK) pathway, which activates a set of transcript...

In response to endoplasmic reticulum (ER) stress, the signaling pathway termed unfolded protein response (UPR) is activated. To investigate the role of UPR in Litopenaeus vannamei immunity, the activating transcription factor 4 (designated as LvATF4) which belonged to a branch of the UPR, the [protein kinase RNA (PKR)-like ER kinase, (PERK)]-[eukaryotic initiation factor 2 subunit alpha (eIF2α)...

Yeast cells respond to the presence of amino acids in their environment by inducing transcription of several amino acid permease genes including AGP1, BAP2, and BAP3. The signaling pathway responsible for this induction involves Ssy1, a permease-like sensor of external amino acids, and culminates with proteolytic cleavage and translocation to the nucleus of the zinc-finger proteins Stp1 and Stp...

Pain is a manifestation of rheumatoid arthritis (RA) that mediated by inflammatory and non-inflammatory mechanisms negatively affects quality life. Recent findings from Phase 3 clinical trial showed patients with RA who were treated Janus kinase 1 (Jak1) 2 (Jak2) inhibitor achieved significantly greater improvements in pain than those tumor necrosis factor blocker; both treatments resulted simi...