Coming Soon 10:15 Networking Coffee Break Critical Issues—The Pharmacokinetics of Transdermal Delivery 10:40 Minimization of CYP2D6 Polymorphic Differences and Improved Bioavailability via Transdermal Administration Thean Yeoh, Ph.D., Associate Research Fellow, Pfizer Transdermal delivery has the potential to offer improved bioavailability by circumventing first-pass gut and hepatic metabolism....

Since oral bioavailability of atenolol and metoprolol tartrate is poor, different matrix –type transdermal patches incorporating atenolol and metoprolol tartrate were formulated with an objective to study the effect of polymers on transdermal release of the drugs. The polymers selected were polyvinylpyrrolidone, cellulose acetate phthalate, hydroxypropylmethylcellulose phthalate and ethyl cellu...

Testosterone replacement has undergone somewhat of a revolution in the past decade with the introduction of topical administration techniques, including patches and gels, as well as an increasing interest in the treatment of older men with low testosterone levels for what is now termed andropause. Increasingly, testosterone replacement therapy is being individually tailored. Side effects to ski...

entaNYL transdermal patches (Duragesic and other generic brands) are a mainstay in the treatment of Fchronic pain, yet the US health care community and patients alike continue to face challenges regarding the safe use of this product. Despite numerous warnings from drug manufacturers, patient safety groups, and even the Food and Drug Administration (FDA), the Institute for Safe Medication Pract...

Purpose. Fentanyl is available as a transdermal system for the treatment of chronic pain in opioid-tolerant patients; however, it carries a black box warning due to both the potency of the product and the potential for abuse. In this report, we describe a case of transbuccal and gastrointestinal ingestion of fentanyl patches and the management of such ingestion. Summary. A 32-year-old man was b...

Heart rate variability (HRV) signal analysis provides a non-invasive and sensitive marker of autonomic nervous system (ANS) activity. Spectral parameters of HRV signal are used to quantify the balance between sympathetic and parasympathetic (sympathovagal) influences under various physiologic conditions. ECG signals were acquired, filtered and further processed to derive the HRV signal. The low...

In the present study, is to development of Azelnidipine (AZP) transdermal patches and to study the effect of Dimethyl sulfoxide (DMSO) on drug permeation through across the rat abdominal skin. The transdermal patches were prepared by solvent casting method using different amounts and combination of hydroxyl propyl methyl cellulose (HPMC E15), Ethyl cellulose (EC) and Eudragit RS100 (ERS). The d...

BACKGROUND Given prior studies demonstrating the marked clinical activity of oral estrogens in prostate cancer, more recent data demonstrating the safety of transdermal estradiol, and the renewed interest in targeting testosterone metabolism and androgen receptor pathways, we report the results of a trial of transdermal estradiol in advanced heavily pre-treated castrate and chemotherapy refract...

Melatonin, a pineal gland hormone can play an important role on circadian rhythms and worked as an internal sleep facilitator in human. Recently, melatonin was used as a drug for treatment of insomnia. The transdermal drug delivery is a good alternative for melatonin delivery because of its variable oral absorption, short half-life, highly first pass metabolism, and a favorable partition coeffi...